{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T22:26:46Z","timestamp":1773959206216,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,2,8]],"date-time":"2011-02-08T00:00:00Z","timestamp":1297123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2011,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>The purpose of this study was to investigate efficacy, safety, and impact on quality of sleep of staggered furosemide and desmopressin in the treatment of nocturia in the elderly.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients aged &gt;60 years with nocturia at least two voids per night were screened for enrollment into the study. A 3\u2010week dose\u2010titration phase established the optimum desmopressin dose (0.1, 0.2, or 0.4\u2009mg). After a 1\u2010week \u201cwashout\u201d period, patients who showed sufficient response during the dose\u2010titration period were randomized to receive staggered furosemide and the optimal dose of desmopressin or placebo in a double\u2010blind design for 3 weeks. Voiding diaries were assessed before and after the treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all, 82 patients were randomized to either staggered furosemide and desmopressin (n\u2009=\u200941) or placebo (n\u2009=\u200941). In the study group, most patients reported a good response with both reduced nocturnal voids (3.5 vs. 2.0, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01) and urine volume (919.6\u2009ml vs. 584.2\u2009ml, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). The mean duration of the first sleep period was improved by 70\u2009min (133.6 vs. 203.2, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). Compared to placebo, staggered furosemide and desmopressin resulted in a significant reduction in the mean number of nocturnal voids (43% vs. 9%; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01), nocturnal urine volume (37% vs. 5%; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01), and increase in the mean duration of the first sleep period (52% vs. 19%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). Adverse events were mild.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Staggered furosemide and desmopressin provide an effective and well\u2010tolerated treatment for nocturia in the elderly. Neurourol. Urodynam. 30:312\u2013316, 2011. \u00a9 2011 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.20986","type":"journal-article","created":{"date-parts":[[2011,2,9]],"date-time":"2011-02-09T11:55:37Z","timestamp":1297252537000},"page":"312-316","source":"Crossref","is-referenced-by-count":27,"title":["Reducing nocturia in the elderly: A randomized placebo\u2010controlled trial of staggered furosemide and desmopressin"],"prefix":"10.1002","volume":"30","author":[{"given":"Fei\u2010Guo","family":"Fu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugh J.","family":"Lavery","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deng\u2010Long","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,2,8]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2008.04.002"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2005.12.002"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2007.01462.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20484"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410X.1998.00511.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2008.08.517"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410X.90.s3.3.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.2008.02246.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0210-4806(07)73632-X"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.2165\/00002512-200724040-00005"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410X.90.s3.7.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000136203.76320.f6"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410x.1999.00012.x"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(01)01645-4"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2007.01.027"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410X.2002.02791.x"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1067\/S0002-9378(03)00593-3"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20038"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20168"}],"container-title":["Neurourology and Urodynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fnau.20986","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fnau.20986","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.20986","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T14:58:28Z","timestamp":1696690708000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/nau.20986"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2,8]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,3]]}},"alternative-id":["10.1002\/nau.20986"],"URL":"https:\/\/doi.org\/10.1002\/nau.20986","archive":["Portico"],"relation":{},"ISSN":["0733-2467","1520-6777"],"issn-type":[{"value":"0733-2467","type":"print"},{"value":"1520-6777","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2,8]]}}}