{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:13:13Z","timestamp":1772118793997,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2010,12,3]],"date-time":"2010-12-03T00:00:00Z","timestamp":1291334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2011,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Chronic blockade of nitric oxide (NO) synthesis leads to detrusor smooth muscle overactivity. This study aimed to evaluate the protective effects of BAY 41\u20102272, a soluble guanlylate cyclase activator, on changes in cystometric parameters in NO\u2010deficient rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Rats were divided into the following groups: (a) control, (b) DMSO, (c)\n                      <jats:italic>N<\/jats:italic>\n                      <jats:sup>\u03c9<\/jats:sup>\n                      \u2010nitro\u2010\n                      <jats:sc>L<\/jats:sc>\n                      \u2010arginine methyl ester hydrochrolide (L\u2010NAME), (d) BAY 41\u20102272 alone, and (e) L\u2010NAME\u2009+\u2009BAY 41\u20102272. The NO synthase blocker L\u2010NAME (20\u2009mg\/rat\/day) was giving in the drinking water concomitantly or not with BAY 41\u20102272 (10\u2009mg\/kg\/day, given by gavage).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Chronic L\u2010NAME treatment markedly increased the mean arterial blood pressure (MABP), and co\u2010treatment with BAY 41\u20102272 nearly reversed L\u2010NAME\u2010induced rise on MABP. Non\u2010void contractions were significantly increased in L\u2010NAME group (0.90\u2009\u00b1\u20090.1 number\/min) compared with either DMSO or control group (0.49\u2009\u00b1\u20090.1 number\/min), which were prevented by co\u2010treatment with BAY 41\u20102271 (0.56\u2009\u00b1\u2009025 number\/min;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05). The threshold pressure and peak pressure increased by 70% and 44% after chronic L\u2010NAME treatment, while co\u2010treatment with BAY 41\u20102272 largely attenuated both of these effects (27% and 22% increase, respectively). The frequency of micturition cycles decreased by about of 50% in L\u2010NAME\u2010treated rats compared with control animals, and co\u2010treatment with BAY 41\u20102272 normalized this parameter.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our data show that long\u2010term oral administration of BAY 41\u20102272 counteracts the bladder dysfunction seen in NO\u2010deficient rats, indicating that restoration of the NO\u2010cGMP pathway by this compound may be of beneficial value to treat bladder symptoms. Neurourol. Urodynam. 30:456\u2013460, 2011. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/nau.20992","type":"journal-article","created":{"date-parts":[[2010,12,3]],"date-time":"2010-12-03T13:19:22Z","timestamp":1291382362000},"page":"456-460","source":"Crossref","is-referenced-by-count":18,"title":["Long\u2010term administration of BAY 41\u20102272 prevents bladder dysfunction in nitric oxide\u2010deficient rats"],"prefix":"10.1002","volume":"30","author":[{"given":"Fab\u00edola Z.","family":"M\u00f3nica","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Reges","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio 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