{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T04:18:48Z","timestamp":1774325928516,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2011,4,21]],"date-time":"2011-04-21T00:00:00Z","timestamp":1303344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>We retrospectively investigated the efficacy of methylphenidate (MPH) in giggle incontinence (GI), and the relationship between GI and urodynamic parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Nine (n\u2009=\u20099) female GI patients underwent 1 year of treatment with 5\u2009mg MPH. Three questionnaires, voiding diaries, and UDS were conducted before and after treatment. The severity of GI was classified into mild, moderate, and severe. Clinical success was characterized as: full response, response, partial response, and non\u2010response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age of all patients was 16.2\u2009\u00b1\u20092.3 years. Five patients had mild, one had moderate, and three had severe grade incontinent. All patients reported complete cessation of wetting after MPH treatment. The mean duration of asymptomatic period was 7\u2009\u00b1\u20093.2 months. There were no statistically significant score changes in all three questionnaires: Urgency Perception Scale (UPS), Overactive Bladder Symptom Score (OABSS) and Primary Overactive Symptom Questionnaire (POSQ), and voiding diaries (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). In UDS, there were no statistically significant altered parameters, except maximum urethral closure pressure (MUCP) and maximum urethral pressure (MUP). After treatment, the mean MUCP was increased from 52.2\u2009\u00b1\u20096.8 to 73.0\u2009\u00b1\u20095.4\u2009cmH<jats:sub>2<\/jats:sub>O (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), and the mean MUP was increased from 48.6\u2009\u00b1\u20097.3 to 70.2\u2009\u00b1\u20095.0\u2009cmH<jats:sub>2<\/jats:sub>O (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>MPH can be a viable option for the primary treatment of GI, and it may be related to increasing urethral closure pressure. It was not possible to establish if a relationship between GI and detrusor overactivity exists. Neurourol. Urodynam. 30:1338\u20131342, 2011. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.21046","type":"journal-article","created":{"date-parts":[[2011,4,21]],"date-time":"2011-04-21T20:08:43Z","timestamp":1303416523000},"page":"1338-1342","source":"Crossref","is-referenced-by-count":20,"title":["Clinical and urodynamic effect of methylphenidate for the treatment of giggle incontinence (enuresis risoria)"],"prefix":"10.1002","volume":"30","author":[{"given":"Joo\u2010Hyun","family":"Chang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwang\u2010Yeom","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae\u2010Beom","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang\u2010Jin","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tack","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khae\u2010Hawn","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,4,21]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"1335","article-title":"Enuresis risoria (giggle micturition)","volume":"119","author":"De Jonge GA","year":"1975","journal-title":"Ned Tijdschr Geneeskd"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.1979.tb02887.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(06)00305-3"},{"key":"e_1_2_6_5_2","first-page":"358","article-title":"Micturition induced by giggling","volume":"34","author":"MacKeith RC","year":"1959","journal-title":"Ach Dis Child"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)64350-9"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)65776-8"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.04.085"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.279.14.1100"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)80023-3"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1053\/smrv.1999.0069"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2004.02.008"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/nau.1930110509"},{"key":"e_1_2_6_14_2","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/S0022-3565(24)37579-2","article-title":"Therapeutic effects of dopamine D1\/D2 receptor agonists on detrusor hyperreflexia in 1\u2010methyl\u20104phenyl\u20101,2,3,6\u2010tetrahydropyridine\u2010lesioned parkinsonian cynomolgus monkeys","volume":"286","author":"Yoshimura N","year":"1998","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.108.139386"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(11)64618-1"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20260"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20652"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.56.3.232"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1982.03320350050029"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00120-007-1333-6"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.1995.tb00773.x"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199937060-00002"}],"container-title":["Neurourology and Urodynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fnau.21046","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.21046","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T05:54:09Z","timestamp":1741154049000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/nau.21046"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4,21]]},"references-count":22,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["10.1002\/nau.21046"],"URL":"https:\/\/doi.org\/10.1002\/nau.21046","archive":["Portico"],"relation":{},"ISSN":["0733-2467","1520-6777"],"issn-type":[{"value":"0733-2467","type":"print"},{"value":"1520-6777","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,4,21]]}}}