{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T19:29:38Z","timestamp":1765826978105},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2011,4,20]],"date-time":"2011-04-20T00:00:00Z","timestamp":1303257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>We evaluated a putative central inhibitory effect of intravesical botulinum toxin A (BoNT\u2010A) on the activity of lumbosacral spinal neurons in a chronic spinal cord injury (SCI) model of bladder overactivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Female Sprague\u2010Dawley rats underwent T8 spinal cord transection. Four weeks later, once overactive neuropathic detrusor pathways had developed, the animals underwent intravesical instillation with either saline (1\u2009ml) or BoNT\u2010A (Botox\u00ae, 20\u2009U\/1\u2009ml) for 1\u2009hr. Two days later, the rats then completed a cystometric evaluation prior to spinal cord harvest. Sections from the L4\u2010S1 spinal cord segments were examined for the total number of c\u2010fos immunoreactive cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Comparison of the saline and BoNT\u2010A treated groups showed a significant decrease in L6 (i.e., 67%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and S1 (i.e., 47%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01) c\u2010fos expression (43%) in BoNT\u2010A treated rats compared to saline controls. Cystometrogram studies revealed that the frequency of non\u2010voiding bladder contractions was reduced by 73% (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) in BoNT\u2010A compared to saline treated rats. No change in the frequency of voiding bladder contractions or amplitude of bladder contraction was observed between the saline and BoNT\u2010A treated groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In a SCI model of bladder overactivity, intravesical BoNT\u2010A significantly inhibits the response of bladder afferent activated lumbosacral neurons without significantly impairing efferent bladder function. Neurourol. 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