{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:16:37Z","timestamp":1791090997457,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,6,9]],"date-time":"2011-06-09T00:00:00Z","timestamp":1307577600000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A substantial portion of the current research on lower urinary tract dysfunction is focused on afferent mechanisms. The main goals are to define and modulate the signaling pathways by which afferent information is generated, enhanced and conveyed to the central nervous system. Alterations in bladder afferent mechanisms are a potential source of voiding dysfunction and an emerging source for drug targets. Established drug therapies such as muscarinic receptor antagonists, and two emerging therapies, \u03b2<jats:sub>3<\/jats:sub>\u2010adrenergic receptor agonists and botulinum toxin type\u2010A, may act partly through afferent mechanisms. This review focuses on these two new principles and new and established methods for determining their sites of action. It also provides brief information on the innervation of the bladder, afferent receptors and transmitters and how these may communicate with the urothelium, interstitial cells and detrusor smooth muscle to regulate micturition. Peripheral and central mechanisms of afferent sensitization and myogenic mechanisms that lead to detrusor overactivity, overactive bladder symptoms and urgency sensations are also covered. This work is the result from \u2018Think Tank\u2019 presentations, and the lengthy discussions that followed, at the 2010 International Consultation on Incontinence Research Society meeting in Bristol, UK. Neurourol. Urodynam. Neurourol. Urodynam. 30:684\u2013691, 2011. \u00a9 2011 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/nau.21102","type":"journal-article","created":{"date-parts":[[2011,6,14]],"date-time":"2011-06-14T09:44:39Z","timestamp":1308044679000},"page":"684-691","source":"Crossref","is-referenced-by-count":42,"title":["Researching bladder afferents\u2014determining the effects of \u03b2<sub>3<\/sub>\u2010adrenergic receptor agonists and botulinum toxin type\u2010A"],"prefix":"10.1002","volume":"30","author":[{"given":"Anthony","family":"Kanai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Jacques","family":"Wyndaele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl\u2010Erik","family":"Andersson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Fry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youko","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Zabbarova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"De Wachter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,6,9]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"33","volume-title":"Nervous control of the urogenital system. Vol. 3","author":"Lincoln JBG","year":"1993"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(97)00587-6"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ar.10029"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1994.71.6.2046"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.01049.2007"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.140244"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.12.060"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.1996.tb02579.x"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1993.69.2.395"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903100309"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2004.02.014"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1838(94)90069-8"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-11-04644.1999"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00162.2006"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.12.022"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.2008.02052.x"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1997.503bb.x"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2005.08.014"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2010.10.035"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2005.088435"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-15-05670.2001"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20940"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2007.11.006"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2004.06.001"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00056.2003"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00552.2004"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1474-8673.2002.00258.x"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2007.01.046"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2010.07.034"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2009.08423.x"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2010.04.012"},{"key":"e_1_2_5_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20208"},{"key":"e_1_2_5_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2007.02.057"},{"key":"e_1_2_5_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2008.04.038"},{"key":"e_1_2_5_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-010-1053-x"},{"key":"e_1_2_5_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20826"},{"key":"e_1_2_5_38_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1998.275.2.F226"},{"key":"e_1_2_5_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2004.06.073"},{"key":"e_1_2_5_40_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-1331.2001.00035.x"},{"key":"e_1_2_5_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2008.11.009"},{"key":"e_1_2_5_42_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2007.07312.x"},{"key":"e_1_2_5_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2008.10.139"},{"key":"e_1_2_5_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)61994-3"},{"key":"e_1_2_5_45_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-008-0274-y"},{"key":"e_1_2_5_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-0115(01)00285-3"},{"key":"e_1_2_5_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)67505-0"},{"key":"e_1_2_5_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2007.01.038"},{"key":"e_1_2_5_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2009.07.016"},{"key":"e_1_2_5_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(95)00453-X"},{"key":"e_1_2_5_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2007.02.010"}],"container-title":["Neurourology and Urodynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fnau.21102","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.21102","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T09:57:28Z","timestamp":1696931848000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/nau.21102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6]]},"references-count":50,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["10.1002\/nau.21102"],"URL":"https:\/\/doi.org\/10.1002\/nau.21102","archive":["Portico"],"relation":{},"ISSN":["0733-2467","1520-6777"],"issn-type":[{"value":"0733-2467","type":"print"},{"value":"1520-6777","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,6]]}}}