{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T00:07:35Z","timestamp":1721693255112},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,3,30]],"date-time":"2012-03-30T00:00:00Z","timestamp":1333065600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To assess the effects of different doses and treatment durations of Pregabalin and Lamotrigine on the urodynamic parameters of an animal model of neurogenic detrusor overactivity (NDO).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Ninety rats were used; six as normal controls and the remaining 84 were divided as follows: Six \u201cparaplegic controls,\u201d 6 \u201cparaplegic\u2010vehicle controls,\u201d and the remaining 72 divided into two equal groups. Group 1 was divided into six subgroups; Pregabalin was given in doses of 10\u2009mg\/kg, 20\u2009mg\/kg, or 30\u2009mg\/kg for 1 or 2 weeks. Group 2 was similarly subdivided; Lamotrigine was given in doses of 1.5\u2009mg\/kg, 3\u2009mg\/kg, or 6\u2009mg\/kg for 1 or 2 weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All paraplegic controls developed NDO within 3 weeks from spinalization. Their baseline bladder pressure (BBP) 19\u2009\u00b1\u20094.4\u2009cmH<jats:sub>2<\/jats:sub>O, detrusor pressure at maximum capacity (DPMaxC) 47.6\u2009\u00b1\u20094.3\u2009cmH<jats:sub>2<\/jats:sub>O, bladder capacity (BC) 0.45\u2009\u00b1\u20090.1\u2009ml, and frequency of detrusor overactivity (FDO) 3.7\u2009\u00b1\u20090.9\/min. Both Pregabalin and Lamotrigine produced significant improvement. Urodynamic values in those treated with 20\u2009mg Pregabalin for 1 or 2 weeks were: BBP 11.7\u2009\u00b1\u20091.3 and 9\u2009\u00b1\u20090.2\u2009cmH<jats:sub>2<\/jats:sub>O, BC 0.6\u2009\u00b1\u20090.1 and 0.7\u2009\u00b1\u20090.01\u2009ml, DPMaxC 17.3\u2009\u00b1\u20094.0 and 23\u2009\u00b1\u20092.6\u2009cmH<jats:sub>2<\/jats:sub>O, FDO 2.1\u2009\u00b1\u20090.2\/min and 1.7\u2009\u00b1\u20090.1\/min. Urodynamic values in those treated with 3\u2009mg\/kg Lamotrigine for 1 or 2 weeks were: BBP 9.7\u2009\u00b1\u20092.2 and 8.6\u2009\u00b1\u20091.9\u2009cmH<jats:sub>2<\/jats:sub>O, DPMaxC 17.2\u2009\u00b1\u20091.8 and 29\u2009\u00b1\u20091.2\u2009cmH<jats:sub>2<\/jats:sub>O, BC 0.7\u2009\u00b1\u20090.1 and 0.8\u2009\u00b1\u20090.1\u2009ml, FDO 1.9\u2009\u00b1\u20090.2\/min and 1.9\u2009\u00b1\u20090.2\/min (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Pregabalin and Lamotrigine may represent novel alternative treatments of NDO. Clinical trials remain to be performed. Neurourol. Urodynam. 31:1197\u20131202, 2012. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.21214","type":"journal-article","created":{"date-parts":[[2012,4,3]],"date-time":"2012-04-03T14:19:38Z","timestamp":1333462778000},"page":"1197-1202","source":"Crossref","is-referenced-by-count":13,"title":["Effect of the anticonvulsant medications Pregabalin and Lamotrigine on urodynamic parameters in an animal model of neurogenic detrusor overactivity"],"prefix":"10.1002","volume":"31","author":[{"given":"Oleg","family":"Loutochin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tala 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