{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T16:59:14Z","timestamp":1769187554640,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,8,20]],"date-time":"2012-08-20T00:00:00Z","timestamp":1345420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Pfizer, Inc."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To assess the efficacy and tolerability of fesoterodine 8\u2009mg versus tolterodine extended release (ER) 4\u2009mg in subjects with overactive bladder (OAB) stratified by age (&lt;65, 65\u201374, and \u226575 years).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a post hoc analysis of data from two double\u2010blind trials. Subjects reporting \u22651 urgency urinary incontinence (UUI) episode and \u22658\u2009micturitions\/24\u2009hr at baseline were randomized to fesoterodine (4\u2009mg for 1 week, 8\u2009mg for 11 weeks), tolterodine ER 4\u2009mg, or placebo. Subjects completed 3\u2010day bladder diaries, Urgency Perception Scale (UPS), Patient Perception of Bladder Condition (PPBC), and OAB questionnaire (OAB\u2010q) at baseline and week 12. The primary endpoint in both studies was change from baseline to week 12 in UUI episodes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among subjects &lt;65 years (n\u2009=\u20092,670), improvements in UUI episodes, micturitions, urgency episodes, severe urgency episodes, frequency\u2010urgency sum, UPS, PPBC, and all OAB\u2010q scales and domains were significantly greater with fesoterodine versus tolterodine ER, and diary\u2010dry rates were significantly higher. Among subjects 65\u201374 years (n\u2009=\u2009990), improvements in mean voided volume per void, PPBC, and OAB\u2010q Symptom Bother and Coping were significantly greater with fesoterodine versus tolterodine ER. Among subjects aged \u226575 years (n\u2009=\u2009448), improvements in urgency episodes, severe urgency episodes, frequency\u2010urgency sum, UPS, and OAB\u2010q Symptom Bother were significantly greater with fesoterodine versus tolterodine ER. Both active treatments produced significant improvements in most outcomes versus placebo across age groups. Adverse event rates were similar among age groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Fesoterodine 8\u2009mg consistently improved several OAB\u2010related variables versus tolterodine ER 4\u2009mg in subjects aged &lt;65, 65\u201374, and \u226575 years, with some differences reaching statistical significance, and was generally well tolerated. Neurourol. Urodynam. 31:1258\u20131265, 2012. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.22252","type":"journal-article","created":{"date-parts":[[2012,8,20]],"date-time":"2012-08-20T14:31:53Z","timestamp":1345473113000},"page":"1258-1265","source":"Crossref","is-referenced-by-count":28,"title":["Efficacy and tolerability of fesoterodine versus tolterodine in older and younger subjects with overactive bladder: A post hoc, pooled analysis from two placebo\u2010controlled trials"],"prefix":"10.1002","volume":"31","author":[{"given":"Catherine E.","family":"DuBeau","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jon D.","family":"Morrow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen R.","family":"Kraus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dana","family":"Creanga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamara","family":"Bavendam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,8,20]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/nau.10052"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20798"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2006.09.019"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2010.06.007"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2010.03.014"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2009.08534.x"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2000.tb04744.x"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1998.tb03801.x"},{"key":"e_1_2_7_10_2","first-page":"963","volume-title":"Incontinence","author":"DuBeau C","year":"2009"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.2165\/11539020-000000000-00000"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.22.2716"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1532-5415.2001.49144.x"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1532-5415.2002.50203.x"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1185\/03007X226294"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjopharm.2006.03.004"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2010.03.097"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)64567-3"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2005.05.009"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2009.02108.x"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.9.10.1787"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.5414\/CPP47570"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2007.07.009"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2007.08.033"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2009.09086.x"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2010.09640.x"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1214\/aos\/1176344010"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2008.06.047"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2008.03.027"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2010.02611.x"}],"container-title":["Neurourology and Urodynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fnau.22252","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fnau.22252","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.22252","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T12:25:43Z","timestamp":1696854343000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/nau.22252"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,20]]},"references-count":29,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["10.1002\/nau.22252"],"URL":"https:\/\/doi.org\/10.1002\/nau.22252","archive":["Portico"],"relation":{},"ISSN":["0733-2467","1520-6777"],"issn-type":[{"value":"0733-2467","type":"print"},{"value":"1520-6777","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,20]]}}}