{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T08:58:47Z","timestamp":1762505927045},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,6,5]],"date-time":"2012-06-05T00:00:00Z","timestamp":1338854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>We evaluated whether patients stratified by age have the same level of risks\/benefits after a staged neuromodulation procedure for refractory voiding symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Urologic diagnosis, complications, and revisions were collected from medical records of adults enrolled in our prospective observational study. Symptoms were assessed over 2 years with diaries, Interstitial Symptom\u2010Problem Indices (ICSI\u2010PI), and the Overactive Bladder Questionnaire\u2010SF (OAB\u2010q SF). 12\u2010item Short\u2010Form Health Survey (SF\u201012v2\u00ae) mental (MCS) and physical (PCS) component summaries evaluated quality of life. Data were examined with Pearson Chi\u2010square or Fisher's Exact test, Kruskal\u2010Wallis tests, and repeated measures analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients (83% female) were grouped by age (years): &lt;40 (n\u2009=\u200946), 40\u201364 (n\u2009=\u2009146), and \u226565 (n\u2009=\u2009136). Urge incontinence was predominant in the older groups and more patients &lt;40 had interstitial cystitis\/painful bladder syndrome (IC\/PBS). In the &lt;40, 40\u201364, and \u226565 groups, respectively, generator implant (91%, 88%, and 89%) and explant (15%, 12%, and 10%) rates were similar. Complications (24%, 14%, and 9%; <jats:italic>P<\/jats:italic>\u2009=\u20090.031) and revisions (20%, 5%, and 6%; <jats:italic>P<\/jats:italic>\u2009=\u20090.0025) differed. For the three respective groups, urinary frequency (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001 for all), nocturia (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001 for all), incontinence episodes (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001 for all), urgency (<jats:italic>P<\/jats:italic>\u2009=\u20090.0474, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001, <jats:italic>P<\/jats:italic>\u2009=\u20090.0020), ICSI\u2010PI (<jats:italic>P<\/jats:italic>\u2009=\u20090.0015, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001), and OAB\u2010q scores improved over time. Incontinence severity improved in those &gt;65 (<jats:italic>P<\/jats:italic>\u2009=\u20090.0015). SF\u201012 PCS improved in those 40\u201364 (<jats:italic>P<\/jats:italic>\u2009=\u20090.0482) and MCS scores improved in the &lt;40 and 40\u201364 age groups (<jats:italic>P<\/jats:italic>\u2009=\u20090.013 and <jats:italic>P<\/jats:italic>\u2009=\u20090.0440, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These data suggest that neuromodulation success is not age dependent, however continued study is needed to confirm findings. Neurourol. Urodynam. 32: 30\u201336, 2013. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.22268","type":"journal-article","created":{"date-parts":[[2012,6,5]],"date-time":"2012-06-05T20:23:23Z","timestamp":1338927803000},"page":"30-36","source":"Crossref","is-referenced-by-count":28,"title":["Does patient age impact outcomes of neuromodulation?"],"prefix":"10.1002","volume":"32","author":[{"given":"Kenneth M.","family":"Peters","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim A.","family":"Killinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Gilleran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith A.","family":"Boura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,6,5]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-010-1278-y"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(97)00187-3"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198901053200101"},{"key":"e_1_2_5_5_2","first-page":"2305","volume-title":"Campbell\u2010Walsh urology","author":"Resnick NM","year":"2007"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2010.08.039"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4733.2005.00041.x"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1997.tb12054.x"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20979"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2002.130004"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(02)01841-1"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-003-1070-3"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20174"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(99)80333-1"},{"key":"e_1_2_5_15_2","unstructured":"CoyneKS LaiJS ZyczynskiT et al.An overactive bladder symptom and quality\u2010of\u2010life short form: Development of the Overactive Bladder Questionnaire (OAB\u2010q) short form (SF). Presented at the Joint Meeting of the International Continence Society and the International Urogynecological Association; August 23\u201327 2004. Paris France."},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199603000-00003"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365590310022680"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.06.049"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-011-1512-2"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2005.04.031"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(00)00597-5"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)65979-4"}],"container-title":["Neurourology and Urodynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fnau.22268","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.22268","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T02:38:19Z","timestamp":1700534299000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/nau.22268"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,5]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["10.1002\/nau.22268"],"URL":"https:\/\/doi.org\/10.1002\/nau.22268","archive":["Portico"],"relation":{},"ISSN":["0733-2467","1520-6777"],"issn-type":[{"value":"0733-2467","type":"print"},{"value":"1520-6777","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,5]]}}}