{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T05:10:08Z","timestamp":1793682608363,"version":"4.5.1"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,6,5]],"date-time":"2012-06-05T00:00:00Z","timestamp":1338854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Reflux esophagitis (RE) is a common disease which has been recognized to be associated with several medical co\u2010morbidities. However, the association between RE and bladder pain syndrome\/interstitial cystitis (BPS\/IC) is still unknown. The present study aimed to explore the association between these two diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We identified 8,962 female patients who had received a diagnosis of RE as the study cohort. We randomly selected 44,810 subjects to be included as the comparison cohort. Each patient in this study was individually tracked for a 3\u2010year period to identify those who subsequently received a diagnosis of BPS\/IC. Cox proportional hazards regressions were carried out to estimate the 3\u2010year risk of BPS\/IC following a diagnosis of RE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The incidence of BPS\/IC following a diagnosis of RE was 4.3% during the follow\u2010up period for all subjects. The incidence rate of BPS\/IC was 2.38 [95% confidence interval (CI): 2.21\u20132.57] per 100 person\u2010years in patients with RE, and 1.24 (95% CI: 1.18\u20131.30) per 100 person\u2010years in controls. Cox proportional analysis indicated that the hazard ratio (HR) of BPS\/IC for patients with RE was 2.00 (95% CI\u2009=\u20091.82\u20132.20,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) that of controls. The adjusted HR of BPS\/IC for patients with RE was 1.40 (95% CI\u2009=\u20091.27\u20131.55,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) after taking age group, urbanization level, and medical comorbidity into consideration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We found that patients with RE were at a higher risk than with comparison patients for having been subsequently diagnosed with BPS\/IC during longitudinal follow\u2010up. Neurourol. Urodynam. 32: 271\u2013275, 2013. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/nau.22270","type":"journal-article","created":{"date-parts":[[2012,6,5]],"date-time":"2012-06-05T16:23:48Z","timestamp":1338913428000},"page":"271-275","source":"Crossref","is-referenced-by-count":10,"title":["Reflux esophagitis increased the risk of bladder pain syndrome\/interstitial cystitis: A 3\u2010year follow\u2010up study"],"prefix":"10.1002","volume":"32","author":[{"given":"Jiunn\u2010Horng","family":"Kang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph 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