{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T19:19:54Z","timestamp":1761765594967},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,9,10]],"date-time":"2012-09-10T00:00:00Z","timestamp":1347235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>OnabotulinumtoxinA significantly reduces urinary incontinence (UI) and improves bladder management in patients with neurogenic detrusor overactivity (NDO). We evaluated the impact of onabotulinumtoxinA on patient\u2010reported outcomes (PROs) in patients with UI due to NDO in a double\u2010blind, placebo\u2010controlled study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with UI due to NDO (from multiple sclerosis or spinal cord injury) were randomized to intradetrusor placebo (n\u2009=\u200992) or onabotulinumtoxinA 200\u2009U (n\u2009=\u200992) or 300\u2009U (n\u2009=\u200991). PROs included Incontinence Quality of Life (I\u2010QOL) Questionnaire to assess health\u2010related quality of life (HRQoL), the 16\u2010item modified Overactive Bladder\u2010Patient Satisfaction with Treatment Questionnaire (OAB\u2010PSTQ) to assess treatment satisfaction, and Patient Global Assessment to assess treatment goal achievement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean improvement in I\u2010QOL total score at weeks 6 and 12 was significantly greater with both onabotulinumtoxinA 200\u2009U and 300\u2009U versus placebo (\u039412.3 for 200\u2009U and \u039414.9 for 300\u2009U vs. placebo; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), and was clinically meaningful. For those patients who completed the OAB\u2010PSTQ, improvement in satisfaction at weeks 6 and 12 was significantly greater for onabotulinumtoxinA versus placebo (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001, all comparisons). At 6 weeks, greater proportions of onabotulinumtoxinA\u2010treated patients than placebo reported being somewhat or very satisfied (200\u2009U, 77.5% and 300\u2009U, 67.8% vs. placebo, 39.5%), and significant progress toward or complete achievement of primary treatment goal (200\u2009U, 62.9% and 300\u2009U, 61.6% vs. placebo, 16.5%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>NDO patients treated with onabotulinumtoxinA 200 or 300\u2009U had significantly greater improvement in HRQoL and greater treatment satisfaction compared with placebo\u2010treated patients, with no clinically relevant differences between onabotulinumtoxinA doses. Neurourol. Urodynam. 32: 242\u2013249, 2013. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.22293","type":"journal-article","created":{"date-parts":[[2012,9,10]],"date-time":"2012-09-10T16:38:25Z","timestamp":1347295105000},"page":"242-249","source":"Crossref","is-referenced-by-count":44,"title":["Treatment satisfaction and improvement in health\u2010related quality of life with onabotulinumtoxinA in patients with urinary incontinence due to neurogenic detrusor overactivity"],"prefix":"10.1002","volume":"32","author":[{"given":"David","family":"Sussman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vaishali","family":"Patel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulio","family":"Del 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