{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T05:04:53Z","timestamp":1767848693664,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,9,21]],"date-time":"2012-09-21T00:00:00Z","timestamp":1348185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Bladder pain syndrome\/interstitial cystitis (BPS\/IC) is a chronic pain syndrome of unknown etiology that primarily affects women. Using a longitudinal follow\u2010up design, this study aimed to examine the risk of depressive disorder (DD) among women with BPS\/IC compared to the general population during a 1\u2010year period following their diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This study used data from the Taiwan \u201cLongitudinal Health Insurance Database.\u201d A total of 832 patients with BPS\/IC were included in the study group and 4,160 matched non\u2010BPS\/IC enrollees were included as the comparison group. Each patient (n\u2009=\u20094,992) was individually tracked for a 1\u2010year period to identify those who subsequently received a diagnosis of DD. Cox proportional hazards regressions (stratified by age group and the index year) were used to estimate the risk of subsequent DD following a diagnosis of BPS\/IC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that during the 1\u2010year follow\u2010up, the incidence rate of DD was 4.69 (95% CI: 3.38\u20136.34) per 100 person\u2010years in patients with BPS\/IC and 0.94 (95% CI: 0.68\u20131.27) per 100 person\u2010years in comparison patients. The hazard ratio (HR) of DD during the 1\u2010year follow\u2010up period for patients with BPS\/IC was 5.06 (95% CI: 3.21\u20137.96, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) that of comparison patients after adjusting for patient monthly income, geographic location, and urbanization level. The adjusted HR for DD associated with BPS\/IC was 10.33 for patients aged between 40 and 49 (95% CI: 3.68\u201329.04).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study demonstrated that there is an increased risk for being diagnosed with DD during the first year subsequent to being diagnosed with IC\/PBS. Neurourol. Urodynam. 32: 467\u2013471, 2013. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.22316","type":"journal-article","created":{"date-parts":[[2012,9,21]],"date-time":"2012-09-21T12:07:57Z","timestamp":1348229277000},"page":"467-471","source":"Crossref","is-referenced-by-count":16,"title":["Increased risk of depressive disorder following diagnosis with bladder pain syndrome\/interstitial cystitis"],"prefix":"10.1002","volume":"32","author":[{"given":"Joseph 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