{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T16:31:16Z","timestamp":1778862676279,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>We prospectively investigated the effect of dutasteride on clinical and urodynamic parameters in patients with benign prostatic enlargement (BPE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A prospective study was conducted in consecutive 52 patients with BPE who had not been satisfied with alpha\u2010adrenergic antagonist monotherapy. Inclusion criteria were prostate volume (PV) \u226530\u2009ml and the International Prostate Symptom Score (IPSS) \u22658 or QOL index \u22653 under administration of an alpha\u2010adrenergic antagonist without anticholinergic agent. Before and 24 weeks after dutasteride (0.5\u2009mg daily) add\u2010on treatment with preceding alpha\u2010adrenergic antagonist, we assessed IPSS, uroflowmetry (UFM), filling cystometry, and pressure\u2010flow study (PFS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Dutasteride add\u2010on treatment significantly improved IPSS (from 18.4\u2009\u00b1\u20097.5 to 13.8\u2009\u00b1\u20097.3) and maximum flow rate (from 11.4\u2009\u00b1\u20095.6 to 13.0\u2009\u00b1\u20096.8\u2009ml\/sec). Maximum cystometric capacity on filling cystometry did not change significantly by dutasteride add\u2010on treatment (221\u2009\u00b1\u200997 and 240\u2009\u00b1\u2009104\u2009ml before and after dutasteride add\u2010on, respectively). All of the 41 patients with detrusor overactivity (DO) before dutasteride add\u2010on treatment showed apparent reduction in the amplitude of involuntary detrusor contraction after dutasteride add\u2010on treatment, including seven in whom DO disappeared. Dutasteride significantly reduced PV from 66.4\u2009\u00b1\u200931.9 to 47.6\u2009\u00b1\u200926.1\u2009ml. In PFS, detrusor pressure at maximum flow rate (PdetQmax) significantly decreased from 71.5\u2009\u00b1\u200930.1 to 59.1\u2009\u00b1\u200924.9\u2009cmH<jats:sub>2<\/jats:sub>O after dutasteride add\u2010on treatment. Bladder outlet obstruction index (BOOI) also decreased significantly from 55.2\u2009\u00b1\u200931.9 to 42.3\u2009\u00b1\u200927.9, and obstruction grade assessed by the Sch\u00e4fer nomogram significantly improved.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Dutasteride can improve lower urinary tract symptoms by improving storage bladder function and relieving obstruction. <jats:italic>Neurourol. Urodynam. 32:1123\u20131127, 2013<\/jats:italic>. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.22349","type":"journal-article","created":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T10:52:47Z","timestamp":1374058367000},"page":"1123-1127","source":"Crossref","is-referenced-by-count":18,"title":["Urodynamic effects of dutasteride add\u2010on therapy to alpha\u2010adrenergic antagonist for patients with benign prostatic enlargement: Prospective pressure\u2010flow study"],"prefix":"10.1002","volume":"32","author":[{"given":"Naoki","family":"Wada","sequence":"first","affiliation":[{"name":"Department of Renal and Urologic Surgery Asahikawa Medical University Asahikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masafumi","family":"Kita","sequence":"additional","affiliation":[{"name":"Department of Renal and Urologic Surgery Asahikawa Medical University Asahikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazumi","family":"Hashizume","sequence":"additional","affiliation":[{"name":"Department of Renal and Urologic Surgery Asahikawa Medical University Asahikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiji","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Renal and Urologic Surgery Asahikawa Medical University Asahikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidehiro","family":"Kakizaki","sequence":"additional","affiliation":[{"name":"Department of Renal and Urologic Surgery Asahikawa Medical University Asahikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,7,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/pcan.2009.37"},{"key":"e_1_2_6_3_1","first-page":"677","article-title":"The effect of dutasteride on voiding and storage symptoms in men with benign prostatic hyperplasia","volume":"56","author":"Tsukamoto T","year":"2010","journal-title":"Acta Urol Jpn"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2006.06030.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.08.030"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20802"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)66894-0"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(99)00130-2"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.10052"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410x.1999.00121.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00182666"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2007.09.084"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00182658"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005392-200101000-00008"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.10099"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)64688-5"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2008.02.017"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2010.05.034"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)35300-4"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2006.06735.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.21201"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030330"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.pcan.4500931"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2006-1079"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.2164\/jandrol.107.002774"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-008-0284-x"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1992.tb14483.x"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2008.07521.x"}],"container-title":["Neurourology and Urodynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fnau.22349","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fnau.22349","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.22349","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T01:21:32Z","timestamp":1696382492000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/nau.22349"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,17]]},"references-count":27,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["10.1002\/nau.22349"],"URL":"https:\/\/doi.org\/10.1002\/nau.22349","archive":["Portico"],"relation":{},"ISSN":["0733-2467","1520-6777"],"issn-type":[{"value":"0733-2467","type":"print"},{"value":"1520-6777","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,17]]}}}