{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T07:59:26Z","timestamp":1789718366854,"version":"4.0.1"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Recent research demonstrated that bladder pain syndrome\/interstitial cystitis (BPS\/IC) is associated with many coexisting physical and psychiatric conditions. In this study, we explored the potential association between anxiety disorder (AD) and BPS\/IC using a case\u2013controlled population\u2010based approach in Taiwan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data on the sampled subjects analyzed in this study were retrieved from the Longitudinal Health Insurance Database 2000. Our study included 396 female cases with BPS\/IC and 1,980 randomly selected female controls. We excluded subjects who had a history of major psychosis (except AD) or a substance\u2010related disorder. A conditional logistic regression was performed to calculate the odds ratio (OR) for the association between a previous diagnosis of AD and IC\/BPS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 2,376 sampled subjects, 136 (5.72%) had received an AD diagnosis. AD was found in 64 (16.16%) cases and in 72 (3.64%) controls (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). The conditional logistic regression analysis (conditioned on age group and the index year) suggested that compared to controls, the OR for prior AD among cases was 4.59 (95% confidence interval (CI)\u2009=\u20092.32\u20139.08, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). After adjusting for chronic pelvic pain, irritable bowel syndrome, fibromyalgia, migraines, sicca syndrome, allergies, asthma, and an overactive bladder, the OR for prior AD among cases was 4.37 (95% CI\u2009=\u20092.16\u20138.85, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) compared to the controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There was an association between AD and BPS\/IC, even after taking demographic characteristics, medical co\u2010morbidities, and substance\u2010related disorders into consideration. Results of this study should alert clinicians to evaluate and monitor the presence of BPS\/IC in patients with AD. <jats:italic>Neurourol. Urodynam. 33:101\u2013105, 2014<\/jats:italic>. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.22382","type":"journal-article","created":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T14:39:52Z","timestamp":1377182392000},"page":"101-105","source":"Crossref","is-referenced-by-count":31,"title":["Bladder pain syndrome\/interstitial cystitis is associated with anxiety disorder"],"prefix":"10.1002","volume":"33","author":[{"given":"Kuo\u2010Hsuan","family":"Chung","sequence":"first","affiliation":[{"name":"Departmentof Psychiatry Taipei Medical University Hospital Taipei Taiwan"},{"name":"Psychiatric Research Center Taipei Medical University Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih\u2010Ping","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Urology National Taiwan University Hospital and College of Medicine Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herng\u2010Ching","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Health Care Administration Taipei Medical University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiu\u2010Dong","family":"Chung","sequence":"additional","affiliation":[{"name":"School of Health Care Administration Taipei Medical University Taipei Taiwan"},{"name":"Division of Urology, Department of Surgery Far Eastern Memorial Hospital Ban Ciao, Taipei 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