{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T13:58:31Z","timestamp":1765807111698},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,7,19]],"date-time":"2013-07-19T00:00:00Z","timestamp":1374192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine efficacy and safety of OnabotulinumtoxinA (BoNT\u2010A) injection therapy in medically refractory patients with lower urinary tract symptoms (LUTS) due to primary bladder\u2010neck dysfunction (PBND).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Thirty\u2010five consecutive ambulatory males diagnosed with PBND and refractory to medical therapy, with IPSS\u2009&gt;\u200915, Qmax\u2009&lt;\u200915\u2009ml\/sec, and total prostate volume\u2009&lt;\u200930\u2009cm<jats:sup>3<\/jats:sup>, were screened from January 2010 to December 2011. Eligible patients underwent transurethral bladder\u2010neck injection of BoNT\u2010A (200\u2009U, 50\u2009U\/ml\u2009\u00d7\u20094 sites) and were assessed at baseline, 2\u2010, 6\u2010, 9\u2010, and 12\u2010month postprocedure and until duration of clinical response. The primary outcome was the change from baseline in total IPSS, and secondary outcome were storage\u2010 and voiding\u2010IPSS, QoL score, Qmax, and postvoiding residual volume (PVR), patient\u2010reported outcomes. Adverse effects were also recorded, including ejaculatory dysfunctions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 30 enrolled patients (mean age 33.8 years), 29 (96.7%) completed the study. A statistically significant improvement of total IPSS was observed from 21.9 at baseline, to 7.8, 10.3, and 16.6 at 2, 6, and 9 months, respectively (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.000). Statistically significant improvements from baseline of storage\u2010 and voiding\u2010IPSS, QoL score, Qmax, and PVR were also observed until 9\u2010month postprocedure. The proportion of patients with overall satisfaction was favorable although decreasing from 80% at 2 months, to 44.8% at 12 months. No significant adverse effects or ejaculatory dysfunctions were noted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>BoNT\u2010A injection therapy appears effective and safe in medically refractory men with PBND, although repeated procedures are required for long\u2010term sustained benefit. Randomized controlled trials are warranted in order to corroborate these results. <jats:italic>Neurourol. Urodynam. 33:142\u2013146, 2014<\/jats:italic>. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.22393","type":"journal-article","created":{"date-parts":[[2013,7,19]],"date-time":"2013-07-19T09:19:50Z","timestamp":1374225590000},"page":"142-146","source":"Crossref","is-referenced-by-count":12,"title":["OnabotulinumtoxinA injection therapy in men with LUTS due to primary bladder\u2010neck dysfunction: Objective and patient\u2010reported outcomes"],"prefix":"10.1002","volume":"33","author":[{"given":"Emilio","family":"Sacco","sequence":"first","affiliation":[{"name":"Urologic Clinic, Department of Surgical Sciences, \u201cAgostino Gemelli\u201d Hospital Catholic University School of Medicine Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Tienforti","sequence":"additional","affiliation":[{"name":"Urologic Surgery, Columbus Integrated Complex Hospital Catholic University School of Medicine Rome 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