{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:52:31Z","timestamp":1790707951685,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,8,9]],"date-time":"2013-08-09T00:00:00Z","timestamp":1376006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"crossref","award":["R01 NS050514"],"award-info":[{"award-number":["R01 NS050514"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Clinical application of pudendal nerve (PN) afferent stimulation to restore bladder emptying in persons with neurological disorders requires increased stimulation\u2010evoked voiding efficiencies (VEs). We tested the hypothesis that selective co\u2010stimulation of multiple PN branches, either bilateral dorsal nerve of the penis (DNP) stimulation or selective stimulation of both the cranial sensory nerve (CSN) and DNP, will evoke larger reflex bladder contractions and result in higher VEs than stimulation of any single afferent pathway alone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We measured the strength of bladder contractions, threshold volumes, and VEs produced by unilateral and bilateral stimulation of the DNP as well as singular and selective unilateral co\u2010stimulation of the DNP and CSN in cats anesthetized with \u03b1\u2010chloralose.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Co\u2010stimulation of afferent pathways generated significantly larger isovolumetric bladder contractions and evoked contractions at lower threshold volumes than individual stimulation. Co\u2010stimulation of pudendal afferents also suppressed dyssynergic activity in the external anal sphincter produced by low frequency individual stimulation. VE was significantly improved with co\u2010stimulation (172\u2009\u00b1\u20096% of distention evoked volumes) over individual stimulation (141\u2009\u00b1\u20096%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Both types of co\u2010stimulation evoked larger bladder contractions and increased VE over individual branch PN afferent stimulation and distention\u2010evoked voiding. The decreased threshold volumes required for reflex bladder activation and increased VEs with co\u2010stimulation support the use of stimulation of multiple individual stimulation\u2010evoked reflexes to improve voiding efficiency.\n                      <jats:italic>Neurourol. Urodynam. 33:1272\u20131278, 2014<\/jats:italic>\n                      . \u00a9 2013 Wiley Periodicals, Inc.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/nau.22474","type":"journal-article","created":{"date-parts":[[2013,8,9]],"date-time":"2013-08-09T09:12:45Z","timestamp":1376039565000},"page":"1272-1278","source":"Crossref","is-referenced-by-count":34,"title":["Selective co\u2010stimulation of pudendal afferents enhances bladder activation and improves voiding efficiency"],"prefix":"10.1002","volume":"33","author":[{"given":"Meredith J.","family":"McGee","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering Duke University Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warren M.","family":"Grill","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Duke University Durham North Carolina"},{"name":"Department of Electrical and Computer Engineering Duke University Durham North Carolina"},{"name":"Department of Neurobiology Duke University Medical Center Durham North Carolina"},{"name":"Department of Surgery Duke University Medical Center Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,8,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.10052"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2004.21.1371"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/82.6.601"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(05)52011-9"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.111815"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20374"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00029.2008"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2004.01.001"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.sc.3101177"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20441"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20897"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2010.09.079"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2008.04.010"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00978.2004"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00154.2010"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1993.sp019604"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2008.03.044"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902880206"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(98)00155-4"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01900538"},{"key":"e_1_2_7_22_1","doi-asserted-by":"crossref","first-page":"3090","DOI":"10.1523\/JNEUROSCI.13-07-03090.1993","article-title":"Membrane potential changes in sphincter motoneurons during micturition in the decerebrate cat","volume":"13","author":"Fedirchuk B","year":"1993","journal-title":"J Neurosci"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.40.4.358"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.02.110"},{"key":"e_1_2_7_25_1","doi-asserted-by":"crossref","first-page":"R1560","DOI":"10.1152\/ajpregu.1991.261.6.R1560","article-title":"alpha\u2010Chloralose alters autonomic reflex function of the lower urinary tract","volume":"261","author":"Rudy DC","year":"1991","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1982.sp014020"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2008.07.029"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20544"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-005-0032-4"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2560\/10\/3\/036010"}],"container-title":["Neurourology and Urodynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fnau.22474","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fnau.22474","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.22474","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T03:35:51Z","timestamp":1696476951000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/nau.22474"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,9]]},"references-count":29,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["10.1002\/nau.22474"],"URL":"https:\/\/doi.org\/10.1002\/nau.22474","archive":["Portico"],"relation":{},"ISSN":["0733-2467","1520-6777"],"issn-type":[{"value":"0733-2467","type":"print"},{"value":"1520-6777","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,9]]}}}