{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:16:39Z","timestamp":1791090999391,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":675,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"NIH","award":["R37 DK54824"],"award-info":[{"award-number":["R37 DK54824"]}]},{"name":"NIH","award":["R01 DK57284"],"award-info":[{"award-number":["R01 DK57284"]}]},{"name":"NIH","award":["R01 DK083323"],"award-info":[{"award-number":["R01 DK083323"]}]},{"name":"NIH","award":["K01 DK080184"],"award-info":[{"award-number":["K01 DK080184"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourol. Urodynam."],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1002\/nau.22508","type":"journal-article","created":{"date-parts":[[2013,10,26]],"date-time":"2013-10-26T16:47:46Z","timestamp":1382806066000},"page":"79-84","source":"Crossref","is-referenced-by-count":64,"title":["Effect of botulinum toxin A on urothelial-release of ATP and expression of SNARE targets within the urothelium"],"prefix":"10.1002","volume":"34","author":[{"given":"Ann T.","family":"Hanna-Mitchell","sequence":"first","affiliation":[{"name":"Department of Medicine; University of Pittsburgh School of Medicine; Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda S.","family":"Wolf-Johnston","sequence":"additional","affiliation":[{"name":"Department of Medicine; University of Pittsburgh School of Medicine; Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey R.","family":"Barrick","sequence":"additional","affiliation":[{"name":"Department of Pharmacology; University of Pittsburgh School of Medicine; Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony J.","family":"Kanai","sequence":"additional","affiliation":[{"name":"Department of Medicine; University of Pittsburgh School of Medicine; Pittsburgh Pennsylvania"},{"name":"Department of Pharmacology; University of Pittsburgh School of Medicine; Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael B.","family":"Chancellor","sequence":"additional","affiliation":[{"name":"Oakland University-William Beaumont School of Medicine; Royal Oak Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William C.","family":"de Groat","sequence":"additional","affiliation":[{"name":"Department of Pharmacology; University of Pittsburgh School of Medicine; Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori A.","family":"Birder","sequence":"additional","affiliation":[{"name":"Department of Medicine; University of Pittsburgh School of Medicine; Pittsburgh Pennsylvania"},{"name":"Department of Pharmacology; University of Pittsburgh School of Medicine; Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,10,26]]},"reference":[{"key":"10.1002\/nau.22508-BIB0001|nau22508-cit-0001","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/ncpuro1124","article-title":"Drug insight: Biological effects of botulinum toxin A in the lower urinary tract","volume":"5","author":"Chancellor","year":"2008","journal-title":"Nat Clin Pract Urol"},{"key":"10.1002\/nau.22508-BIB0002|nau22508-cit-0002","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/nrurol.2010.187","article-title":"Repeat botulinum toxin-A injections for treatment of adult detrusor overactivity","volume":"7","author":"Dowson","year":"2010","journal-title":"Nat Rev Urol"},{"key":"10.1002\/nau.22508-BIB0003|nau22508-cit-0003","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1097\/01.ju.0000169481.42259.54","article-title":"Decreased sensory receptors P2\u2009\u00d7\u20093 and TRPV1 in suburothelial nerve fibers following intradetrusor injections of botulinum toxin for human detrusor overactivity","volume":"174","author":"Apostolidis","year":"2005","journal-title":"J Urol"},{"key":"10.1002\/nau.22508-BIB0004|nau22508-cit-0004","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1016\/j.eururo.2012.03.031","article-title":"Botulinum neurotoxin serotype A suppresses neurotransmitter release from afferent as well as efferent nerves in the urinary bladder","volume":"62","author":"Ikeda","year":"2012","journal-title":"Eur Urol"},{"key":"10.1002\/nau.22508-BIB0005|nau22508-cit-0005","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/ncpuro0672","article-title":"Mechanisms of disease: Involvement of the urothelium in bladder dysfunction","volume":"4","author":"Birder","year":"2007","journal-title":"Nat Clin Pract Urol"},{"key":"10.1002\/nau.22508-BIB0006|nau22508-cit-0006","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1097\/01.ju.0000127725.48479.89","article-title":"Emerging role of botulinum toxin in the management of voiding dysfunction","volume":"171","author":"Smith","year":"2004","journal-title":"J Urol"},{"key":"10.1002\/nau.22508-BIB0007|nau22508-cit-0007","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/j.neuint.2007.11.006","article-title":"Botulinum toxin type A normalized alterations in urothelial ATP and NO release induced by chronic spinal cord injury","volume":"52","author":"Smith","year":"2008","journal-title":"Neurochem Int"},{"key":"10.1002\/nau.22508-BIB0008|nau22508-cit-0008","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/j.eururo.2009.12.022","article-title":"Distribution of the high-affinity binding site and intracellular target of botulinum toxin type A in the human bladder","volume":"57","author":"Coelho","year":"2010","journal-title":"Eur Urol"},{"key":"10.1002\/nau.22508-BIB0009|nau22508-cit-0009","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1113\/jphysiol.2004.071159","article-title":"Expression and function of bradykinin B1 and B2 receptors in normal and inflamed rat urinary bladder urothelium","volume":"562","author":"Chopra","year":"2005","journal-title":"J Physiol"},{"key":"10.1002\/nau.22508-BIB0010|nau22508-cit-0010","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1748-1716.2012.02462.x","article-title":"Alteration in TRPV1 and muscarinic (M3) receptor expression and function in idiopathic overactive bladder urothelial cells","volume":"207","author":"Birder","year":"2013","journal-title":"Acta Physiol"},{"key":"10.1002\/nau.22508-BIB0011|nau22508-cit-0011","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.eururo.2008.05.007","article-title":"Intravesical botulinum toxin A administration inhibits COX-2 and EP4 expression and suppresses bladder hyperactivity in cyclophosphamide-induced cystitis in rats","volume":"56","author":"Chuang","year":"2009","journal-title":"Eur Urol"},{"key":"10.1002\/nau.22508-BIB0012|nau22508-cit-0012","doi-asserted-by":"crossref","first-page":"2578","DOI":"10.1016\/j.juro.2010.07.034","article-title":"Immunohistochemical expression of muscarinic receptors in the urothelium and suburothelium of neurogenic and idiopathic overactive bladders, and changes with botulinum neurotoxin administration","volume":"184","author":"Datta","year":"2010","journal-title":"J Urol"},{"key":"10.1002\/nau.22508-BIB0013|nau22508-cit-0013","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1111\/j.1442-2042.2011.02946.x","article-title":"Botulinum toxin type A for the treatment of lower urinary tract disorders","volume":"19","author":"Yokoyama","year":"2012","journal-title":"Int J Urol"},{"key":"10.1002\/nau.22508-BIB0014|nau22508-cit-0014","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1016\/j.juro.2012.12.022","article-title":"Onabotulinum toxin A for the treatment of patients with overactive bladder and urinary incontinence: Results of a phase 3 randomized placebo-controlled trial","volume":"189","author":"Nitti","year":"2013","journal-title":"J Urol"},{"key":"10.1002\/nau.22508-BIB0015|nau22508-cit-0015","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.eururo.2010.02.031","article-title":"Trigonal injection of botulinum toxin A in patients with refractory bladder pain syndrome\/interstitial cystitis","volume":"58","author":"Pinto","year":"2012","journal-title":"Eur Urol"},{"key":"10.1002\/nau.22508-BIB0016|nau22508-cit-0016","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1016\/j.juro.2012.07.001","article-title":"Differential effects of botulinum neurotoxin A on bladder contractile responses to activation of efferent nerves, smooth muscles and afferent nerves in rats","volume":"188","author":"Takahashi","year":"2012","journal-title":"J Urol"},{"key":"10.1002\/nau.22508-BIB0017|nau22508-cit-0017","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1016\/j.febslet.2006.02.074","article-title":"The synaptic vesicle protein 2C mediates the uptake of botulinum neurotoxin A into phrenic nerves","volume":"580","author":"Mahrhold","year":"2006","journal-title":"FEBS Lett"},{"key":"10.1002\/nau.22508-BIB0018|nau22508-cit-0018","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1078\/0171-9335-00326","article-title":"The maintenance of the permeability barrier of bladder facet cells requires a continuous fusion of discoid vesicles with the apical plasma membrane","volume":"82","author":"Born","year":"2003","journal-title":"Eur J Cell Biol"},{"key":"10.1002\/nau.22508-BIB0019|nau22508-cit-0019","doi-asserted-by":"crossref","first-page":"5997","DOI":"10.1523\/JNEUROSCI.20-16-05997.2000","article-title":"A novel SNAP-25-caveolin complex correlates with the onset of persistent synaptic potentiation","volume":"20","author":"Braun","year":"2000","journal-title":"J Neurosci"},{"key":"10.1002\/nau.22508-BIB0020|nau22508-cit-0020","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1093\/cercor\/12.4.349","article-title":"Abnormalities of SNARE mechanism proteins in anterior frontal cortex in severe mental illness","volume":"12","author":"Honer","year":"2002","journal-title":"Cerebral Cortex"},{"key":"10.1002\/nau.22508-BIB0021|nau22508-cit-0021","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1111\/j.1464-410X.2007.07312.x","article-title":"Botulinum toxin type A inhibits sensory neuropeptide release in rat bladder models of acute injury and chronic inflammation","volume":"101","author":"Lucioni","year":"2008","journal-title":"BJU Int"},{"key":"10.1002\/nau.22508-BIB0022|nau22508-cit-0022","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1097\/01.ju.0000049202.56189.54","article-title":"Effect of botulinum toxin A on the autonomic nervous system of the rat lower urinary tract","volume":"169","author":"Smith","year":"2003","journal-title":"J Urol"},{"key":"10.1002\/nau.22508-BIB0023|nau22508-cit-0023","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.neuroscience.2010.11.040","article-title":"The effect of botulinum neurotoxin A on sciatic nerve injury-induced neuroimmunological changes in rat dorsal root ganglia and spinal cord","volume":"175","author":"Mika","year":"2011","journal-title":"Neuroscience"},{"key":"10.1002\/nau.22508-BIB0024|nau22508-cit-0024","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.scr.2011.01.002","article-title":"Embryonic stem cell-derived motoneurons provide a highly sensitive cell culture model for botulinum neurotoxin studies, with implications for high-throughput drug discovery","volume":"6","author":"Kiris","year":"2001","journal-title":"Stem Cell Res"},{"key":"10.1002\/nau.22508-BIB0025|nau22508-cit-0025","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1007\/s11302-011-9271-6","article-title":"In pursuit of P2\u2009\u00d7\u20093 antagonists: Novel therapeutics for chronic pain and afferent sensitization","volume":"8","author":"Ford","year":"2012","journal-title":"Purinergic Signal"},{"key":"10.1002\/nau.22508-BIB0026|nau22508-cit-0026","first-page":"F279","article-title":"Modulation of bladder function by luminal adenosine turnover and A1 receptor activation","volume":"303","author":"Prakasam","year":"2012","journal-title":"Am J Physiol"},{"key":"10.1002\/nau.22508-BIB0027|nau22508-cit-0027","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1091\/mbc.E08-04-0439","article-title":"Distinct apical and basolateral membrane requirements for stretch-induced membrane traffic at the apical surface of bladder umbrella cells","volume":"20","author":"Yu","year":"2009","journal-title":"Mol Biol Cell"},{"key":"10.1002\/nau.22508-BIB0028|nau22508-cit-0028","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1038\/emboj.2010.91","article-title":"Compensatory endocytosis in bladder umbrella cells occurs through an integrin-regulated and RhoA- and dynamin-dependent pathway","volume":"29","author":"Khanderwal","year":"2010","journal-title":"EMBO J"},{"key":"10.1002\/nau.22508-BIB0029|nau22508-cit-0029","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1172\/JCI24086","article-title":"ATP and purinergic receptor-dependent membrane traffic in bladder umbrella cells","volume":"115","author":"Wang","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1002\/nau.22508-BIB0030|nau22508-cit-0030","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1126\/science.1123654","article-title":"SV2 is the protein receptor for botulinum neurotoxin A","volume":"312","author":"Dong","year":"2006","journal-title":"Science"},{"key":"10.1002\/nau.22508-BIB0031|nau22508-cit-0031","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.eururo.2004.07.011","article-title":"Lack of ultrastructural detrusor changes following endoscopic injection of botulinum toxin type A in overactive neurogenic bladder","volume":"46","author":"Haferkamp","year":"2004","journal-title":"Eur Urol"},{"key":"10.1002\/nau.22508-BIB0032|nau22508-cit-0032","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.eururo.2009.09.023","article-title":"In the human urothelium and suburothelium, intradetrusor botulinum neurotoxin type A does not induce apoptosis: Preliminary results","volume":"57","author":"Kessler","year":"2010","journal-title":"Eur Urol"},{"key":"10.1002\/nau.22508-BIB0033|nau22508-cit-0033","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.neuint.2012.05.001","article-title":"Botulinum toxin's axonal transport from periphery to the spinal cord","volume":"61","author":"Matak","year":"2012","journal-title":"Neurochem Int"},{"key":"10.1002\/nau.22508-BIB0034|nau22508-cit-0034","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1111\/j.1600-0854.2012.01369.x","article-title":"Botulinum neurotoxin A impairs neurotransmission following retrograde transynaptic transport","volume":"13","author":"Restani","year":"2012","journal-title":"Traffic"},{"key":"10.1002\/nau.22508-BIB0035|nau22508-cit-0035","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1124\/jpet.104.066845","article-title":"Structural features of the botulinum neurotoxin molecule that govern binding and transcytosis across polarized human intestinal epithelial cells","volume":"310","author":"Maksymowych","year":"2004","journal-title":"J Pharm Exp Ther"},{"key":"10.1002\/nau.22508-BIB0036|nau22508-cit-0036","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1083\/jcb.128.6.1019","article-title":"SNAP-25 is expressed in islets of langerhans and is involved in insulin release","volume":"128","author":"Sadoul","year":"1995","journal-title":"J Cell Biol"},{"key":"10.1002\/nau.22508-BIB0037|nau22508-cit-0037","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1111\/j.1464-410X.2007.07137.x","article-title":"Persistence of the synaptosomal-associated protein-25 cleavage product after intradetrusor botulinum toxin A injections in patients with myelomeningocele showing an inadequate response to treatment","volume":"100","author":"Schulte-Baukloh","year":"2007","journal-title":"BJU Int"},{"key":"10.1002\/nau.22508-BIB0038|nau22508-cit-0038","doi-asserted-by":"crossref","first-page":"C775","DOI":"10.1152\/ajpcell.2001.280.4.C775","article-title":"Role of SNAP-23 in trafficking of H+-ATPase in cultured inner medullary collecting duct cells","volume":"280","author":"Banerjee","year":"2001","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1002\/nau.22508-BIB0039|nau22508-cit-0039","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1091\/mbc.E03-09-0684","article-title":"SNAP-23 functions in docking\/fusion of granules at low Ca2+","volume":"15","author":"Chieregatti","year":"2004","journal-title":"Mol Biol Cell"},{"key":"10.1002\/nau.22508-BIB0040|nau22508-cit-0040","doi-asserted-by":"crossref","first-page":"702","DOI":"10.4065\/84.8.702","article-title":"Botulinum A toxin\/dimethyl sulfoxide bladder instillations for women with refractory idiopathic detrusor overactivity: A phase 1\/2 study","volume":"84","author":"Petrou","year":"2009","journal-title":"Mayo Clin Proc"},{"key":"10.1002\/nau.22508-BIB0041|nau22508-cit-0041","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.juro.2009.03.083","article-title":"Urodynamic and immunohistochemical evaluation of intravesical botulinum toxin A delivery using liposomes","volume":"182","author":"Chuang","year":"2009","journal-title":"J Urol"},{"key":"10.1002\/nau.22508-BIB0042|nau22508-cit-0042","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1038\/nn0902-823","article-title":"Synaptic vesicle fusion and synaptotagmin: 2B or not 2B","volume":"5","author":"O'Connor","year":"2002","journal-title":"Nat Neurosci"}],"container-title":["Neurourology and Urodynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fnau.22508","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/nau.22508","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,18]],"date-time":"2024-05-18T23:08:58Z","timestamp":1716073738000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/nau.22508"}},"subtitle":["Botulinum Toxin Effect on Urothelial Targets"],"short-title":[],"issued":{"date-parts":[[2013,10,26]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"URL":"https:\/\/doi.org\/10.1002\/nau.22508","relation":{},"ISSN":["0733-2467"],"issn-type":[{"value":"0733-2467","type":"print"}],"subject":[],"published":{"date-parts":[[2013,10,26]]}}}