{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:18:56Z","timestamp":1761743936939,"version":"3.37.3"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,4,9]],"date-time":"2014-04-09T00:00:00Z","timestamp":1397001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000265","name":"UK Medical Research Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Institute for Health Research (NIHR) Biomedical Research Centre based at Imperial College Healthcare NHS Trust and Imperial College London"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Previous studies have noted an association between a diagnosis of overactive bladder and bacteriuria, but little is understood about the relationship of bacteriuria to specific LUTS. We hypothesized that bacteriuria in women would be associated with increased self\u2010reported symptom scores for a wide range of LUTS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Women were recruited from general gynecology and urogynecology outpatient clinics in a secondary care setting. Women completed the 12\u2010item International Consultation on Incontinence Questionnaire for Female Lower Urinary Tract Symptoms and provided a clean\u2010catch mid\u2010stream specimen of urine for microscopy and culture. Women with acute urinary tract infection were excluded. Three statistical approaches (Mann\u2013Whitney U\u2010test, multivariable logistic regression, and receiver operating characteristic curves) were used to assess differences in symptom scores between women with and without bacteriuria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two hundred forty\u2010seven women were recruited, aged 22\u201382. Sixteen of 247 urine samples (6.5%) demonstrated significant bacteriuria, growing a different range of organisms. Women with significant bacteriuria were more likely to have nocturia (OR 3.56, 95% CI 1.19\u201310.6, <jats:italic>P<\/jats:italic>\u2009=\u20090.02), urgency (OR 6.66, 95% CI 1.47\u201330.06, <jats:italic>P<\/jats:italic>\u2009=\u20090.01), bladder pain (OR 2.82, 95% CI 1\u20137.92, <jats:italic>P<\/jats:italic>\u2009=\u20090.049), urgency incontinence (OR 2.92, 95% CI 1.02\u20138.36, <jats:italic>P<\/jats:italic>\u2009=\u20090.046), nocturnal enuresis (OR 4.21, 95% CI 1.32\u201313.41, <jats:italic>P<\/jats:italic>\u2009=\u20090.01). After adjustment for age, parity, symptomatic prolapse, menopausal status and history of mid\u2010urethral sling urinary urgency, bladder pain, nocturia, and nocturnal enuresis remained significantly associated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Bacteriuria is associated with a range of LUTS including nocturia, urgency, and bladder pain supporting a role for bacterial colonization in the pathogenesis of OAB symptoms. <jats:italic>Neurourol. Urodynam. 34:429\u2013433, 2015<\/jats:italic>. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.22607","type":"journal-article","created":{"date-parts":[[2014,4,9]],"date-time":"2014-04-09T16:03:00Z","timestamp":1397059380000},"page":"429-433","source":"Crossref","is-referenced-by-count":20,"title":["Associations between individual lower urinary tract symptoms and bacteriuria in random urine samples in women"],"prefix":"10.1002","volume":"34","author":[{"given":"Felice","family":"Sorrentino","sequence":"first","affiliation":[{"name":"Department of Urogynaecology St Mary's Hospital London United Kingdom"},{"name":"Department of Medical and Surgical Sciences, Institute of Obstetrics and Gynaecology University of Foggia Foggia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rufus","family":"Cartwright","sequence":"additional","affiliation":[{"name":"Department of Urogynaecology St Mary's Hospital London United Kingdom"},{"name":"Department of Epidemiology and Biostatistics Imperial College London London United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. Alessandro","family":"Digesu","sequence":"additional","affiliation":[{"name":"Department of Urogynaecology St Mary's Hospital London United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise","family":"Tolton","sequence":"additional","affiliation":[{"name":"Institute for Reproductive and Developmental Biology Imperial College London London United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larissa","family":"Franklin","sequence":"additional","affiliation":[{"name":"Women's Health Research Centre Imperial College London London United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anand","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Urogynaecology St Mary's Hospital London United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pantaleo","family":"Greco","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, Institute of Obstetrics and Gynaecology University of Foggia Foggia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vik","family":"Khullar","sequence":"additional","affiliation":[{"name":"Department of Urogynaecology St Mary's Hospital London United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,4,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20798"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000195"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.10.058"},{"key":"e_1_2_7_5_1","first-page":"591","article-title":"Post\u2010partum incontinence, BMI and lower urinary tract symptoms at midlife: 12\u2010Year follow\u2010up of a population\u2010based prospective cohort","volume":"32","author":"Bray R","year":"2013","journal-title":"Neurourol 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