{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T20:15:44Z","timestamp":1780431344006,"version":"3.54.1"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,9,11]],"date-time":"2014-09-11T00:00:00Z","timestamp":1410393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>We assessed the lower urinary tract symptoms (LUTS) and urodynamic findings in patients with neuromyelitis optica spectrum disorders (NMO\u2010SD), a recently defined neurological disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We prospectively evaluated seven men and 23 women (mean age 41.1\u2009\u00b1\u200913.5 years) with an established diagnosis of NMO\u2010SD who were invited to participate irrespective of the presence of LUTS. Neurological evaluation was assessed with the Expanded Disability Status Scale (EDSS) and LUTS were evaluated with the Overactive Bladder questionnaire (OAB\u2010V8) and the International Prostate Symptom Score (I\u2010PSS). All patients underwent videourodynamics, transabdominal urinary tract sonography, urine culture, and serum creatinine levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean time of disease duration was 33.8\u2009\u00b1\u200930.8 months. Neurological evaluation showed a mean EDSS score of 5.3\u2009\u00b1\u20091.8. The most frequent videourodynamic findings were detrusor\u2010sphincter dyssynergia (DSD) and detrusor overactivity (DO) in 11 (36.6%) patients, DSD without DO in seven (23.3%) and DO without DSD in six (20.0%) patients. Voiding dysfunction assessed by I\u2010PSS and OAB\u2010V8 increased with the degree of neurological impairment (<jats:italic>P<\/jats:italic>\u2009=\u20090.018; r\u2009=\u20090.42 and <jats:italic>P<\/jats:italic>\u2009=\u20090.006; r\u2009=\u20090.48 respectively). Patients with DSD had higher I\u2010PSS (18.5\u2009\u00b1\u200911.4 vs 7.0\u2009\u00b1\u20099.2; <jats:italic>P<\/jats:italic>\u2009=\u20090.029) and OAB\u2010V8 scores (22.8\u2009\u00b1\u200915.8vs 9.1\u2009\u00b1\u20097.8; <jats:italic>P<\/jats:italic>\u2009=\u20090.008), and worse neurological impairment (mean EDSS 5.9\u2009\u00b1\u20091.8 vs 4.5\u2009\u00b1\u20091.5; <jats:italic>P<\/jats:italic>\u2009=\u20090.027).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Most patients with NMO\u2010SD have LUTS and voiding dysfunction, with DSD and DO as the main urodynamic findings. The severity of the neurological disease is a predictive factor for the occurrence of voiding dysfunction and detrusor\u2010sphincter dyssynergia. <jats:italic>Neurourol. Urodynam. 35:39\u201343, 2016<\/jats:italic>. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.22667","type":"journal-article","created":{"date-parts":[[2014,9,11]],"date-time":"2014-09-11T16:18:45Z","timestamp":1410452325000},"page":"39-43","source":"Crossref","is-referenced-by-count":24,"title":["Voiding dysfunction in patients with neuromyelitis optica spectrum disorders"],"prefix":"10.1002","volume":"35","author":[{"given":"Fabricio Leite","family":"de Carvalho","sequence":"first","affiliation":[{"name":"Division of Urology University of Sao Paulo School of Medicine Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiano Mendes","family":"Gomes","sequence":"additional","affiliation":[{"name":"Division of Urology University of Sao Paulo School of Medicine Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samira 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