{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:10:33Z","timestamp":1792782633840,"version":"4.5.0"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Astellas; the Belgian Federal Government","award":["IUAP P7\/13"],"award-info":[{"award-number":["IUAP P7\/13"]}]},{"name":"Research Council of the KU Leuven","award":["PFV\/10\/006"],"award-info":[{"award-number":["PFV\/10\/006"]}],"id":[{"id":"https:\/\/ror.org\/05f950310","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Neurogenic bladder dysfunction is a major issue in Multiple Sclerosis (MS). High intravesical pressure should be treated early. Available therapies are insufficient and there is need for drug development and investigation of pathogenesis. Experimental Autoimmune Encephalomyelitis (EAE) in rodents is a well validated model to study MS. Previous research has shown that these animals develop urinary symptoms. However, from clinical studies, we know that symptoms do not necessarily reflect changes in bladder pressure. This paper aims to provide a complete overview of urodynamic changes in a model for detrusor overactivity in MS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Female C57Bl\/6J mice, injected with MOG\n                      <jats:sub>35\u201355<\/jats:sub>\n                      and control mice, injected with vehicle (Complete Freund's adjuvant), were monitored daily for neurologic symptoms. Within 1 month after symptom development, mice were used for cystometry or histology of the bladder.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Increasing disease score correlated with increased micturition frequency, basal pressure, and average pressure, and with a decrease in functional bladder capacity, voiding amplitude, and maximum pressure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This paper provides a detailed description of bladder function in C57Bl\/6J mice with Myelin Oligodendrocyte Glycoprotein peptide (MOG\n                      <jats:sub>35\u201355<\/jats:sub>\n                      ) induced EAE. This EAE model induces detrusor overactivity in close relationship to neurological impairment. EAE in mice is a suitable model to study detrusor overactivity in MS.\n                      <jats:italic>Neurourol. Urodynam. 35:450\u2013456, 2016<\/jats:italic>\n                      . \u00a9 2015 Wiley Periodicals, Inc.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/nau.22742","type":"journal-article","created":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T16:53:06Z","timestamp":1425228786000},"page":"450-456","source":"Crossref","is-referenced-by-count":13,"title":["Urodynamic changes in mice with experimental autoimmune encephalomyelitis correlate with neurological impairment"],"prefix":"10.1002","volume":"35","author":[{"given":"J.","family":"Franken","sequence":"first","affiliation":[{"name":"Department of Development and Regeneration, Laboratory of Experimental Urology UZ Leuven \u2013 University of Leuven Leuven Belgium"},{"name":"Department of Cellular and Molecular Medicine, Laboratory of Ion Channel Research and TRP Research Platform Leuven (TRPLe) KU Leuven \u2013 University of Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Gevaert","sequence":"additional","affiliation":[{"name":"Department of Development and Regeneration, Laboratory of Experimental Urology UZ Leuven \u2013 University of Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Uvin","sequence":"additional","affiliation":[{"name":"Department of Development and Regeneration, Laboratory of Experimental Urology UZ Leuven \u2013 University of Leuven Leuven Belgium"},{"name":"Department of Cellular and Molecular Medicine, Laboratory of Ion Channel Research and TRP Research Platform Leuven (TRPLe) KU Leuven \u2013 University of Leuven Leuven Belgium"},{"name":"Hasselt University \u2013 Biomedical Research Institute Diepenbeek Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Wauterickx","sequence":"additional","affiliation":[{"name":"Hasselt University \u2013 Biomedical Research Institute Diepenbeek Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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