{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T18:50:59Z","timestamp":1785783059069,"version":"3.56.0"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,3,8]],"date-time":"2015-03-08T00:00:00Z","timestamp":1425772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>To verify the efficacy, safety and tolerability of intravesical administration of 0.1% oxybutynin hydrochloride compared to its oral administration for treatment of neurogenic detrusor overactivity (NDO) in a randomized, prospective, controlled, open\u2010label, multi\u2010center trial in 35 adult patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>NDO was confirmed within the previous 24 months by urodynamic studies (UDS). Group 1 (n\u2009=\u200918) received 10\u2009ml 0.1% oxybutynin hydrochloride intravesically three times per day and group 2 (n\u2009=\u200917) 5\u2009mg oxybutynin hydrochloride orally three times per day for a period of 28 days. Primary efficacy criterion was the change in the maximum bladder capacity between the beginning of the study and after 4 weeks as assessed by UDS. Adverse drug reactions (ADR) were collected and an evaluation of anticholinergic effects was conducted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The increase in maximum bladder capacity was 117\u2009ml with intravesical application (<jats:italic>P<\/jats:italic>\u2009=\u20090.0002) versus 18\u2009ml with the oral application (<jats:italic>P<\/jats:italic>\u2009=\u20090.51). The difference was statistically significant (<jats:italic>P<\/jats:italic>\u2009=\u20090.0086). ADR were reported by 10 (55.6%) of patients with intravesical administration, and by 14 (82.4%) of patients with oral administration. Significant differences in favor of the intravesical application were observed in ADR affecting vision (1\/10 vs. 9\/14), gastrointestinal tract (8\/10 vs. 14\/14), nervous system (2\/10 vs. 8\/14), and skin and subcutis (1\/10 vs. 6\/14). No serious adverse drug reactions were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study demonstrates the efficacy and safety of intravesical 0.1% oxybutynin hydrochloride in the treatment of NDO with respect to the increase in maximum bladder capacity. <jats:italic>Neurourol. 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