{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:51:33Z","timestamp":1790833893097,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,4,24]],"date-time":"2015-04-24T00:00:00Z","timestamp":1429833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Buddhist Tzu Chi General Hospital","award":["ICRD 102-02; IRB TCGH 101-91"],"award-info":[{"award-number":["ICRD 102-02; IRB TCGH 101-91"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>Intravesical onabotulinumtoxinA (BoNT\u2010A) injection is a beneficial treatment for interstitial cystitis\/bladder pain syndrome (IC\/BPS), yet its therapeutic efficacy remains to be validated. This study tests efficacy and safety of intravesical BoNT\u2010A injections for treatment of IC\/BPS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A multicenter, randomized, double\u2010blind, placebo<jats:styled-content>\u2010<\/jats:styled-content>controlled trial in patients with IC\/BPS refractory to conventional treatment. Patients were randomized in a 2:1 ratio to hydrodistention plus suburothelial injections of BoNT\u2010A 100\u2009U (Botox group) or the equivalent amount of normal saline (N\/S group). The primary endpoint was a decrease in pain assessed using a visual analog scale (VAS) at week 8 after treatment. Secondary endpoints included voiding diary and urodynamic variables. The Wilcoxon sign rank and rank sum tests were used for statistical analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 60 patients (8 males, 52 females, age 50.8\u2009\u00b1\u200913.9 years) including 40 in the Botox and 20 in the N\/S groups were enrolled. At week 8, a significantly greater reduction of pain was observed in the Botox group compared to the N\/S group (\u22122.6\u2009\u00b1\u20092.8 vs. \u22120.9\u2009\u00b1\u2009 2.2, <jats:italic>P<\/jats:italic>\u2009=\u20090.021). The other variables did not differ significantly between groups except for cystometric bladder capacity, which was increased significantly in the Botox group. The overall success rates were 63% (26\/40) in the Botox group and 15% (3\/20) in the N\/S group (<jats:italic>P<\/jats:italic>\u2009=\u20090.028). Adverse events did not differ between the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Intravesical injections of 100\u2009U of BoNT\u2010A effectively reduced bladder pain symptoms in patients with IC\/BPS. The adverse events were acceptable. <jats:italic>Neurourol. Urodynam. 35:609\u2013614, 2016<\/jats:italic>. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.22760","type":"journal-article","created":{"date-parts":[[2015,4,24]],"date-time":"2015-04-24T20:46:24Z","timestamp":1429908384000},"page":"609-614","source":"Crossref","is-referenced-by-count":99,"title":["Intravesical botulinum toxin\u2010A injections reduce bladder pain of interstitial cystitis\/bladder pain syndrome refractory to conventional treatment \u2013 A prospective, multicenter, randomized, double\u2010blind, placebo\u2010controlled clinical trial"],"prefix":"10.1002","volume":"35","author":[{"given":"Hann\u2010Chorng","family":"Kuo","sequence":"first","affiliation":[{"name":"Department of Urology Buddhist Tzu Chi General Hospital and Tzu Chi University Hualien Taiwan"},{"name":"School of Medicine Tzu Chi University Hualien Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan\u2010Hong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Urology Buddhist Tzu Chi General Hospital and Tzu Chi University Hualien Taiwan"},{"name":"School of Medicine Tzu Chi University Hualien Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao\u2010Chou","family":"Tsai","sequence":"additional","affiliation":[{"name":"School of Medicine Tzu Chi University Hualien Taiwan"},{"name":"Division of Urology Department of Surgery Taipei Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation New Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuh\u2010Chen","family":"Kuo","sequence":"additional","affiliation":[{"name":"School of Medicine Tzu Chi University Hualien Taiwan"},{"name":"Department of Urology Yangming Branch of Taipei City Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,4,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(01)01112-8"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2707"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0b013e32801158df"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2006.08.1108"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2006.08.1109"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442-2042.10.s1.4.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1999.277.2.C271"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000137844.77524.97"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2007.07312.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000169481.42259.54"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2003.12.004"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2004.06.073"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000087173"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2005.12.002"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(06)00258-8"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2004.06.001"},{"key":"e_1_2_6_18_1","first-page":"414","article-title":"Botulinum toxin type A (BTX\u2010A) reduces inflammatory pain in the rat formalin model","volume":"20","author":"Cui M","year":"2000","journal-title":"Cephalalgia"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2007.10.032"},{"key":"e_1_2_6_20_1","first-page":"E15","article-title":"Repeated onabotulinumtoxin\u2010A injections provide better results than single injection in treatment of painful bladder syndrome","volume":"16","author":"Kuo HC","year":"2013","journal-title":"Pain Physician"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2012.11466.x"},{"key":"e_1_2_6_22_1","unstructured":"HannoP. 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