{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T13:58:20Z","timestamp":1764079100160},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,4,14]],"date-time":"2015-04-14T00:00:00Z","timestamp":1428969600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIH\/NIDDK","award":["R01 DK093917 (to A.L.B.)"],"award-info":[{"award-number":["R01 DK093917 (to A.L.B.)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>To characterize the prevalence and impact of nocturnal enuresis and overactive bladder (OAB) symptomatology in the adult sickle\u2010cell disease (SCD) population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a single\u2010center, cross\u2010sectional study of adult SCD patients from October 2012 to February 2014, using the validated Pfizer OAB short form questionnaire and brief voiding history surveys. Patient responses and scores were compared to that of controls having normal or sickle cell trait hemoglobin genotypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A group of 239 SCD patients (116 males, 123 females) were compared with 104 normal and 57 sickle cell trait patients. Seven of 239 (2.9%) SCD patients compared to none of the 161 patients without SCD (<jats:italic>P<\/jats:italic>\u2009=\u20090.04) reported current nocturnal enuresis. The median age of nocturnal enuresis cessation was higher in SCD patients (12.0, IQR 9.0\u201315.0 years) compared to that of both normal (7.5, IQR 6.0\u20139.8 years) and sickle cell trait (7.5, IQR 6.0\u20138.8 years) groups (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). Ninety\u2010three of 239 (38.9%) SCD patients compared to 17 of 104 (16.3%) normal and 11 of 57 (19.3%) sickle cell trait had scores indicating OAB symptomatology (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). Patients with SCD had higher OAB symptom severity and lower health\u2010related quality of life (HRQL) scores compared to the normal and sickle cell trait groups (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001 and <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We demonstrate an elevated rate of nocturnal enuresis and OAB symptoms in the adult SCD population. An OAB phenotype may be an under\u2010recognized complication of SCD irrespective of age. <jats:italic>Neurourol. 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