{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:58:00Z","timestamp":1790517480163,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,7,24]],"date-time":"2015-07-24T00:00:00Z","timestamp":1437696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science, and Technology","doi-asserted-by":"publisher","award":["15K10619"],"award-info":[{"award-number":["15K10619"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science, and Technology","doi-asserted-by":"publisher","award":["25293334"],"award-info":[{"award-number":["25293334"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Hydrodistension of the bladder, with optional fulguration of Hunner lesions, is one of the recommended therapies for interstitial cystitis (IC). The aims of this study are to evaluate long\u2010term outcomes of hydrodistension and identify outcome predictors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study cohort was 191 newly diagnosed IC patients (155 women and 36 men) who underwent hydrodistension with fulguration of Hunner lesions if detected between 2007 and 2013 at our institution. The primary outcome was therapeutic failure, which was defined as repeat hydrodistension, bladder instillation therapy, or narcotic use for pain control. Clinical features, including comorbidities and endoscopic findings, were analyzed along with the outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cohort comprised 126 patients of Hunner type IC and 65 patients of non\u2010Hunner type IC. The mean time to therapeutic failure was 28.5 months in Hunner type IC and 25.2 months in non\u2010Hunner type IC. The therapeutic failure rate was higher in non\u2010Hunner type IC at 17.3 months; however, the long\u2010term outcomes reversed thereafter. The mean time to therapeutic failure was shorter in patients with lumbar spinal stenosis (LSS) or irritable bowel syndrome (IBS). Multivariate analysis identified LSS as a predictor for failure in Hunner type IC and non\u2010Hunner type IC (HR\u2009=\u200918.8, <jats:italic>P<\/jats:italic>\u2009=\u20090.001; HR\u2009=\u20093.8, <jats:italic>P<\/jats:italic>\u2009=\u20090.028, respectively) and IBS in non\u2010Hunner type IC (HR\u2009=\u200918.0, <jats:italic>P<\/jats:italic>\u2009=\u20090.008).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Bladder hydrodistension, with fulguration of the Hunner lesions, improved IC symptoms. The outcome was worse in non\u2010Hunner type IC shortly after hydrodistension but eventually comparable across the two types. Concomitant LSS and IBS were predictors for poor outcome. <jats:italic>Neurourol. Urodynam. 35:965\u2013969, 2016<\/jats:italic>. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.22837","type":"journal-article","created":{"date-parts":[[2015,7,24]],"date-time":"2015-07-24T13:46:49Z","timestamp":1437745609000},"page":"965-969","source":"Crossref","is-referenced-by-count":42,"title":["Hydrodistension with or without fulguration of hunner lesions for interstitial cystitis: Long\u2010term outcomes and prognostic predictors"],"prefix":"10.1002","volume":"35","author":[{"given":"Aya","family":"Niimi","sequence":"first","affiliation":[{"name":"Department of Urology, Graduate School of Medical University of Tokyo Bunkyo\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Nomiya","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Medical University of Tokyo Bunkyo\u2010ku Tokyo Japan"},{"name":"Department of Urology Mitsui Memorial Hospital Chiyoda\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukio","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Medical University of Tokyo Bunkyo\u2010ku Tokyo Japan"},{"name":"Department of Urology Japan Red Cross Medical Centre Shibuya\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motofumi","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Teishin Hospital Chiyoda\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Fujimura","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Medical University of Tokyo Bunkyo\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Fukuhara","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Medical University of Tokyo Bunkyo\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruki","family":"Kume","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Medical University of Tokyo Bunkyo\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiko","family":"Igawa","sequence":"additional","affiliation":[{"name":"Department of Continence Medicine, Graduate School of Medical University of Tokyo Bunkyo\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukio","family":"Homma","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Medical University of Tokyo Bunkyo\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.2009.02326.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2007.09.019"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2011.03.064"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.1930130503"},{"key":"e_1_2_6_6_1","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S0022-5347(17)37314-7","article-title":"Interstitial cystitis: Increased sympathetic innervation and related neuropeptide synthesis","volume":"7","author":"Hohenfellner M","year":"1992","journal-title":"J Urol"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.1990.tb14894.x"},{"key":"e_1_2_6_8_1","first-page":"1495","article-title":"Interstitial cystitis: Its treatment by overdistension of the bladder","volume":"13","author":"Bumpus HCJ.","year":"1930","journal-title":"Med Clin North Am"},{"key":"e_1_2_6_9_1","first-page":"143","article-title":"Conservative therapy of interstitial cystitis","volume":"9","author":"Hanno PM","year":"1991","journal-title":"Semin Urol"},{"key":"e_1_2_6_10_1","first-page":"24","article-title":"The efficacy of hydrodistension of the bladder for interstitial cystitis","volume":"2","author":"Tomoe H","year":"2004","journal-title":"J Interstit Cyst"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.08.013"},{"key":"e_1_2_6_12_1","volume-title":"Interstitial cystitis: an introduction to the problem","author":"Wein A","year":"1990"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2013.05.049"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2014.09.012"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000282832"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.5980\/jpnjurol1989.90.564"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0302-2838(01)00006-9"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2010.06.005"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2011.04.030"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00395.2005"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1994.80.6.0971"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2011.10.036"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.12308"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199711150-00019"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00776-013-0496-9"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e3181b1fb76"}],"container-title":["Neurourology and Urodynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fnau.22837","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fnau.22837","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.22837","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T20:27:10Z","timestamp":1696364830000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/nau.22837"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,24]]},"references-count":25,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.1002\/nau.22837"],"URL":"https:\/\/doi.org\/10.1002\/nau.22837","archive":["Portico"],"relation":{},"ISSN":["0733-2467","1520-6777"],"issn-type":[{"value":"0733-2467","type":"print"},{"value":"1520-6777","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,24]]}}}