{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:54:28Z","timestamp":1791842068866,"version":"4.3.4"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,7,31]],"date-time":"2015-07-31T00:00:00Z","timestamp":1438300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>\n                      Voiding dysfunction in adult men may be caused by bladder outlet obstruction (BOO) and\/or detrusor underactivity (DU). Until now, it is only possible to classify BOO and DU by pressure\u2010flow analysis. Low values of the maximum Watts factor (W\n                      <jats:sub>max<\/jats:sub>\n                      ) indicate DU but thresholds for the diagnosis have not been established. Purpose of this study was to construct a nomogram using bladder outlet resistance and detrusor contractility in order to classify BOO and DU simultaneously.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Treatment na\u00efve men aged \u226540 years with uncomplicated lower urinary tract symptoms (LUTS) were prospectively evaluated. Patients were assessed with IPSS, prostate volume, uroflowmetry, post\u2010void residual, and pressure\u2010flow measurement. The bladder outlet obstruction index (BOOI) was used to determine BOO\u2010grade and W\n                      <jats:sub>max<\/jats:sub>\n                      to calculate detrusor contractility. Individual BOOI\u2010W\n                      <jats:sub>max<\/jats:sub>\n                      values were plotted in a graph. Linear interpolation was applied to determine the 10th, 25th, 50th, 75th, and 90th percentiles.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Retrospective analysis of 822 male patients with means of 64 years, IPSS 16, and prostate volume of 40 cc. Patient and clinical parameters of the &lt;25th percentile groups were significantly different compared to the 25th\u201350th percentiles: age (66 vs. 63 years,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.006), bladder capacity (503 vs. 442\u2009ml,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.009), post\u2010void residual urine (167 vs. 116\u2009ml,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.001), and voiding efficiency (67% vs. 73%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.015).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The nomogram quantifies the relationship between detrusor contractility and BOO in men with LUTS. A measurement value &lt;25th percentile correlates with clinical indicators of DU and is proposed as a cut\u2010off value for DU\u2010diagnosis. Higher age, bladder capacity, and PVR as well as lower voiding efficiency indicate DU.\n                      <jats:italic>Neurourol. Urodynam. 35:980\u2013986, 2016<\/jats:italic>\n                      . \u00a9 2015 Wiley Periodicals, Inc.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/nau.22841","type":"journal-article","created":{"date-parts":[[2015,7,31]],"date-time":"2015-07-31T16:36:58Z","timestamp":1438360618000},"page":"980-986","source":"Crossref","is-referenced-by-count":43,"title":["Unravelling detrusor underactivity: Development of a bladder outlet resistance\u2014Bladder contractility nomogram for adult male patients with lower urinary tract symptoms"],"prefix":"10.1002","volume":"35","author":[{"given":"Matthias","family":"Oelke","sequence":"first","affiliation":[{"name":"Department of Urology Hannover Medical School Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin L. J.","family":"Rademakers","sequence":"additional","affiliation":[{"name":"Department of Urology Maastricht University Medical Centre Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gommert A.","family":"van Koeveringe","sequence":"additional","affiliation":[{"name":"Department of Urology Maastricht University Medical Centre Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the FORCE Research Group, Maastricht & Hannover","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,31]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.10052"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20798"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.4111\/kju.2012.53.5.342"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2006.00917.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2006.11.019"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198901053200101"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410X.1998.00813.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2008.02.017"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410x.1999.00121.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00182664"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00182666"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00182667"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00255533"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-014-1358-6"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.10066"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.1930080104"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2006.05.001"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.21097"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2013.03.031"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2014.07.013"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2010.09.007"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2003.04719.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.22590"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)64054-0"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0195-6701(87)90127-7"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0094-0143(21)00968-X"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.1930080104"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/1520-6777(2001)20:2<175::AID-NAU20>3.0.CO;2-T"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1569-9056(14)60680-1"}],"container-title":["Neurourology and Urodynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fnau.22841","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.22841","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T16:26:30Z","timestamp":1696350390000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/nau.22841"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,31]]},"references-count":29,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.1002\/nau.22841"],"URL":"https:\/\/doi.org\/10.1002\/nau.22841","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.725693549.793511729","asserted-by":"object"}]},"ISSN":["0733-2467","1520-6777"],"issn-type":[{"value":"0733-2467","type":"print"},{"value":"1520-6777","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,31]]}}}