{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T07:47:35Z","timestamp":1759564055118,"version":"3.37.3"},"reference-count":24,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T00:00:00Z","timestamp":1438905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"CONACyT","award":["225126 y 106226"],"award-info":[{"award-number":["225126 y 106226"]}]},{"DOI":"10.13039\/501100004849","name":"Universidad Aut\u00f3noma de Tlaxcala","doi-asserted-by":"crossref","award":["CACyPI-UATx-2014"],"award-info":[{"award-number":["CACyPI-UATx-2014"]}],"id":[{"id":"10.13039\/501100004849","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the morphometry and thyroid\u2010hormone receptor (TR) expression in pelvic (pubococcygeus, Pcm) and perineal (bulbospongiosus, Bsm) muscles of control and hypothyroid female rabbits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Hypothyroidism was induced administering 0.02% methimazole in the drinking water for one month. Hematoxylin\u2010eosin stained muscle sections were used to evaluate the fiber cross\u2010sectional area (CSA) and the number of peripheral myonuclei per fiber. Immunohistochemistry was used to calculate the proportion of TR immunoreactive nuclei per fiber. Significant differences were considered at a <jats:italic>P<\/jats:italic>\u2009\u2264\u20090.05.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>As compared to control rabbits, hypothyroidism increased the averaged fiber CSA and the myonuclei per fiber in the Bsm. Although the myonuclei number per fiber was also increased in the Pcm, the effect concerning the fiber CSA was only observed in a fraction of the Pcm fibers. Both TR\u03b1 and TR\u03b2 were similarly expressed in the Pcm and Bsm. Hypothyroidism increased the expression of the TR\u03b1 in the Bsm. Meanwhile, the expression of TR isoforms in the Pcm was not altered.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings support that the TR signaling is directly involved in morphometrical changes induced by hypothyroidism in the Pcm and Bsm. The effect of hypothyroidism on the Pcm and Bsm could be related to the different type of fiber and metabolism that these muscles have. <jats:italic>Neurourol. Urodynam. 35:895\u2013901, 2016<\/jats:italic>. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.22842","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:40:39Z","timestamp":1438944039000},"page":"895-901","source":"Crossref","is-referenced-by-count":8,"title":["Hypothyroidism modifies morphometry and thyroid\u2010hormone receptor expression in periurethral muscles of female rabbits"],"prefix":"10.1002","volume":"35","author":[{"given":"Octavio","family":"S\u00e1nchez\u2010Garc\u00eda","sequence":"first","affiliation":[{"name":"Centro Tlaxcala de Biolog\u00eda de la Conducta Universidad Aut\u00f3noma de Tlaxcala Tlaxcala M\u00e9xico"},{"name":"Doctorado en Neuroetolog\u00eda Universidad Veracruzana Xalapa M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Rodr\u00edguez\u2010Castel\u00e1n","sequence":"additional","affiliation":[{"name":"Centro Tlaxcala de Biolog\u00eda de la 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