{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T03:34:46Z","timestamp":1780630486252,"version":"3.54.1"},"reference-count":24,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T00:00:00Z","timestamp":1438905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIH","award":["DK088836"],"award-info":[{"award-number":["DK088836"]}]},{"name":"NIH","award":["P01 DK093424"],"award-info":[{"award-number":["P01 DK093424"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>To examine alterations in expression of angiotensin II type 1 receptors (AT1R) which induce organ tissue remodeling, angiotensin II type 2 receptors (AT2R) which protect against it, and related molecules in the bladder of matured rats with bladder dysfunction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Female SD rats of three different ages were used: 8 weeks old (8W; n\u2009=\u20095), 9 months old (9M; n\u2009=\u20095), and 15 months old (15M; n\u2009=\u20095). After cystometry, the expression levels of AT1R, connexin43 (Cx43), MAP kinase (MAPK), collagen1, AT2R, PPAR\u2010\u03b3, adiponectin (Adipo), and adiponectin receptor (Adipo\u2010R) were investigated in the bladder.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Pressure threshold, post\u2010void residual volume and the number of non\u2010voiding contractions were significantly increased in 15M versus 8W rats (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). Maximum voiding pressure was significantly decreased in 15M versus 8W rats (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). There was no significant difference in CMG parameters between 8W and 9M rats. In the bladder, the mRNA expression of AT1R, Cx43, MAPK, collagen 1, AT2R, PPAR\u2010\u03b3, Adipo, and Adipo\u2010R were significantly higher in 15M than in 8W rats. The relative expression ratio of AT1R protein against AT2R protein in the mucosa and detrusor was significantly increased in 15M versus 8W rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results indicate that matured rats exhibit not only bladder overactivity but also impaired voiding, which are associated with upregulation of AT1R. The upregulation of AT2R also may play a significant role in the suppressing of AT1R induced remodelling. However, because AT1R upregulation is more dominant than AT2R increases, AT2R activation may not be sufficient to suppress AT1R stimulation in matured rats. <jats:italic>Neurourol. Urodynam. 35:908\u2013913, 2016<\/jats:italic>. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.22849","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:59:38Z","timestamp":1438945178000},"page":"908-913","source":"Crossref","is-referenced-by-count":7,"title":["Age\u2010related changes in bladder function with altered angiotensin II receptor mechanisms in rats"],"prefix":"10.1002","volume":"35","author":[{"given":"Kenichi","family":"Mori","sequence":"first","affiliation":[{"name":"Department of Urology University of Pittsburgh School of Medicine Pittsburgh Pennsylvania"},{"name":"Department of Urology Oita University Faculty of Medicine Oita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuru","family":"Noguchi","sequence":"additional","affiliation":[{"name":"Department of Urology Saga University Faculty of Medicine Saga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shohei","family":"Tobu","sequence":"additional","affiliation":[{"name":"Department of Urology Saga University Faculty of Medicine Saga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuminori","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Urology Oita University Faculty of Medicine Oita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromitsu","family":"Mimata","sequence":"additional","affiliation":[{"name":"Department of Urology Oita University Faculty of Medicine Oita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradeep","family":"Tyagi","sequence":"additional","affiliation":[{"name":"Department of Urology University of Pittsburgh School of Medicine Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael B.","family":"Chancellor","sequence":"additional","affiliation":[{"name":"Department of Urology Oakland University William Beaumont School of Medicine Royal Oak Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Yoshimura","sequence":"additional","affiliation":[{"name":"Department of Urology University of Pittsburgh School of Medicine Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,8,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198901053200101"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2012.05.002"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000339373"},{"key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/j.1757-5672.2012.00167.x","article-title":"Upregulation of angiotensin II receptor and connexin 43 in increased suburothelial myofibroblasts in the rat inflammatory bladder","volume":"5","author":"Tobu S","year":"2013","journal-title":"LUTS"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00030.2002"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2011.02.018"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2005.05703.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00122.2007"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2010.08.006"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2012.01.022"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/415536a"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(98)00448-2"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc0302.102618"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000094220.06020.C8"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000066684.37829.16"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000203826.15076.4b"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.2170\/jjphysiol.45.823"},{"key":"e_1_2_6_19_1","doi-asserted-by":"crossref","first-page":"3076","DOI":"10.1001\/jama.1987.03390220074024","article-title":"Detrusor hyperactivity with impaired contractile function. 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