{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:15:23Z","timestamp":1790788523250,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,10,7]],"date-time":"2015-10-07T00:00:00Z","timestamp":1444176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ministry of Health, Czech Republic NT","award":["14183-3\/2013"],"award-info":[{"award-number":["14183-3\/2013"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Patients with complete spinal cord injury (SCI) may maintain some perception of bladder fullness. The aim of the study was to evaluate brain activation arising from anticipated extraspinal sensory pathways.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fourteen patients ages 24\u201354 years were enrolled, all having experienced a complete SCI (ASIA A) at C7 to T5 an average of 17 months before study entry. Urodynamic equipment was used for repeated bladder filling and detrusor activity evaluation. All functional magnetic resonance imaging measurements were performed using a Siemens Trio 3T scanner with the GRE\u2010EPI sequence (field of view\u2009=\u2009192\u2009\u00d7\u2009192 mm, voxel 3\u2009\u00d7\u20093\u2009\u00d7\u20093 mm, TR\/TE\u2009=\u20093000\/30\u2009ms, 45 slices). Nine hundred dynamic scans were acquired over 45\u2009min. Statistical analysis was done in SPM8 using a general linear model. Statistics using <jats:italic>t<\/jats:italic>\u2010tests were thresholded at <jats:italic>P<\/jats:italic>\u2009=\u20090.001.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We excluded results from two patients because of activation artifacts. In 8 of 12 patients, significant brain activity was observed during urinary bladder filling. We found significant activation clusters at the nucleus of the solitary tract (NTS) (3\/8), parabrachial nucleus (PBN) (4\/8), hypothalamus (4\/8), thalamus (6\/8), amygdala (7\/8), insular lobe (5\/8), anterior cingulate gyrus (5\/8), and prefrontal cortex (8\/8). Activations in nuclei involved in afferents likely from the vagal nerve (NTS and PBN) correlated significantly with reported bladder sensations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These data suggest that extraspinal sensory pathways may develop following SCI and that vagal nerve may play a role in re\u2010innervation of the urinary bladder. <jats:italic>Neurourol. Urodynam. 36:155\u2013159, 2017<\/jats:italic>. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.22901","type":"journal-article","created":{"date-parts":[[2015,10,7]],"date-time":"2015-10-07T22:26:33Z","timestamp":1444256793000},"page":"155-159","source":"Crossref","is-referenced-by-count":29,"title":["Brain activity on fMRI associated with urinary bladder filling in patients with a complete spinal cord injury"],"prefix":"10.1002","volume":"36","author":[{"given":"Jan","family":"Krhut","sequence":"first","affiliation":[{"name":"Department of Urology University Hospital Ostrava Czech Republic"},{"name":"Department of Surgical Studies Ostrava University Ostrava Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaroslav","family":"Tintera","sequence":"additional","affiliation":[{"name":"Radiodiagnostis and Interventional Radiology Department Institute for Clinical and Experimental Medicine Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina","family":"Bilkova","sequence":"additional","affiliation":[{"name":"Spinal Cord Rehabilitation Unit Rehabilitation Center Kladruby Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr","family":"Holy","sequence":"additional","affiliation":[{"name":"Department of Urology Thomayer Hospital and 1st and 3rd Faculty of Medicine of Charles University Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Zachoval","sequence":"additional","affiliation":[{"name":"Department of Urology Thomayer Hospital and 1st and 3rd Faculty of Medicine of Charles University Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Zvara","sequence":"additional","affiliation":[{"name":"Department of Surgical Studies Ostrava University Ostrava Czech Republic"},{"name":"Division of Urology University of 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