{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:52:49Z","timestamp":1790707969874,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,10,9]],"date-time":"2015-10-09T00:00:00Z","timestamp":1444348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS070267"],"award-info":[{"award-number":["R01NS070267"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Complete spinal cord injury does not block perceptual responses or inferior solitary nucleus activation after genital self\u2010stimulation, even though the vagus is not thought to innervate pelvic structures. We tested if vagus nerve endings sprout after bladder decentralization to innervate genitourinary structures in canines with decentralized bladders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Four reinnervation surgeries were performed in female hounds: bilateral genitofemoral nerve transfer to pelvic nerve with vesicostomy (GNF\u2010V) or without (GFN\u2010NV); and left femoral nerve transfer (FNT\u2010V and FNT\u2010NV). After 8 months, retrograde dyes were injected into genitourinary structures. Three weeks later, at euthanasia, reinnervation was evaluated as increased detrusor pressure induced by functional electrical stimulation (FES). Controls included un\u2010operated, sham\u2010operated, and decentralized animals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Increased detrusor pressure was seen in 8\/12 GFNT\u2010V, 4\/5 GFNT\u2010NV, 5\/5 FNT\u2010V, and 4\/5 FNT\u2010NV animals after FES, but not decentralized controls. Lumbar cord segments contained cells labeled from the bladder in all nerve transfer animals with FES\u2010induced increased detrusor pressure. Nodose ganglia cells labeled from the bladder were observed in 5\/7 nerve transfer animals (1\/2 GNT\u2010NV; 4\/5 FNT\u2010V), and from the clitoris were in 6\/7 nerve transfer animals (2\/2 GFNT\u2010NV; 4\/5 FNT\u2010V). Dorsal motor nucleus vagus cells labeled from the bladder were observed in 3\/5 nerve transfer animals (1\/2 GFNT\u2010NV; 2\/3 FNT\u2010V), and from the clitoris in 4\/5 nerve transfer animals (1\/2 GFNT\u2010NV; 3\/3 FNT\u2010V). Controls lacked this labeling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Evidence of vagal nerve sprouting to the bladder and clitoris was observed in canines with lower motoneuron lesioned bladders. <jats:italic>Neurourol. Urodynam. 36:91\u201397, 2017<\/jats:italic>. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.22904","type":"journal-article","created":{"date-parts":[[2015,10,9]],"date-time":"2015-10-09T20:21:19Z","timestamp":1444422079000},"page":"91-97","source":"Crossref","is-referenced-by-count":14,"title":["Evidence of vagus nerve sprouting to innervate the urinary bladder and clitoris in a canine model of lower motoneuron lesioned bladder"],"prefix":"10.1002","volume":"36","author":[{"given":"Mary F.","family":"Barbe","sequence":"first","affiliation":[{"name":"Department of Anatomy and Cell Biology Temple University School of Medicine Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Gomez\u2010Amaya","sequence":"additional","affiliation":[{"name":"CAIF A1224 University of Pittsburgh School of Medicine Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan S.","family":"Braverman","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology Temple University School of Medicine Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin M.","family":"Brown","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery UCSD Medical Center San Diego California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil S.","family":"Lamarre","sequence":"additional","affiliation":[{"name":"CAIF A1224 University of Pittsburgh School of Medicine Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicky S.","family":"Massicotte","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology Temple University School of Medicine Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer K.S.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology Temple University School of Medicine Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen R.","family":"Dachert","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology Temple University School of Medicine Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Sr.","given":"Michael R.","family":"Ruggieri","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology Temple University School of Medicine Philadelphia Pennsylvania"},{"name":"Shriners Hospital of Philadelphia Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,10,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1000960205"},{"key":"e_1_2_6_3_1","first-page":"323","article-title":"Subdiaphragmatic segments of the vagus nerve in dogs","volume":"24","author":"Obrebowski A","year":"1965","journal-title":"Folia Morphol (Warsz)"},{"key":"e_1_2_6_4_1","first-page":"11","article-title":"The innervation of the distal colon","volume":"42","author":"Mitchell GAG","year":"1935","journal-title":"Edinburgh Med J"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091240105"},{"key":"e_1_2_6_6_1","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/S0016-5085(84)80120-1","article-title":"Comparative anatomy of the myenteric plexus of the distal colon in eight mammals","volume":"86","author":"Christensen J","year":"1984","journal-title":"Gastroenterology"},{"key":"e_1_2_6_7_1","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0094-0143(21)00501-2","article-title":"Anatomy and physiology of the lower urinary tract","volume":"20","author":"de Groat WC","year":"1993","journal-title":"Urol Clin North Am"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-63247-0.00005-5"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2004.027953"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1997.00550240063014"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2004.07.029"},{"key":"e_1_2_6_12_1","first-page":"873","volume-title":"Brain activity associated with urinary bladder filling in poatients with a complete spinal injury (SCI)\u2014a fMRI study. 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