{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:17:23Z","timestamp":1790014643461,"version":"4.0.1"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,11,24]],"date-time":"2015-11-24T00:00:00Z","timestamp":1448323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005616","name":"Allergan, Inc.","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100005616","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>To present final efficacy\/safety results from a prospective, long\u2010term extension trial of onabotulinumtoxinA for urinary incontinence (UI) due to neurogenic detrusor overactivity (NDO); patients received treatment for up to 4 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients who completed a 52\u2010week, phase III trial of onabotulinumtoxinA for NDO were eligible to enter a 3\u2010year, multicenter, open\u2010label extension study of intradetrusor onabotulinumtoxinA (200U or 300U). Patients were treated \u201cas needed\u201d based on their request and fulfillment of prespecified qualification criteria (\u226512 weeks since previous treatment and a UI episode threshold). Assessments included change from study baseline in UI episodes\/day (primary efficacy measure), volume\/void, and Incontinence Quality of Life (I\u2010QOL) total score (week 6); duration of effect; adverse events (AEs); and initiation of de novo clean intermittent catheterization (CIC). Data are presented for up to six treatments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>OnabotulinumtoxinA 200U consistently reduced UI episodes\/day; reductions from baseline ranged from \u20133.2 to \u20134.1 across six treatments. Volume\/void consistently increased, nearly doubling after treatment. I\u2010QOL improvements were consistently greater than twice the minimally important difference (+11 points). Overall median duration of effect was 9.0 months (200U). Results were similar for onabotulinumtoxinA 300U. Most common AEs were urinary tract infections and urinary retention. De novo CIC rates were 29.5, 3.4, and 6.0% (200U), and 43.0, 15.0, and 4.8% (300U) for treatments 1\u20133, respectively; de novo CIC rates were 0% for treatments 4\u20136.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>OnabotulinumtoxinA treatments consistently improve UI, volume\/void, and QOL in patients with UI due to NDO in this 4\u2010year study, with no new safety signals. <jats:italic>Neurourol. Urodynam. 36:368\u2013375, 2017<\/jats:italic>. \u00a9 2015 The Authors. <jats:italic>Neurourology and Urodynamics<\/jats:italic> Published by Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.22934","type":"journal-article","created":{"date-parts":[[2015,11,24]],"date-time":"2015-11-24T14:41:51Z","timestamp":1448376111000},"page":"368-375","source":"Crossref","is-referenced-by-count":72,"title":["Efficacy and safety of onabotulinumtoxinA therapy are sustained over 4 years of treatment in patients with neurogenic detrusor overactivity: Final results of a long\u2010term extension study"],"prefix":"10.1002","volume":"36","author":[{"given":"Michael","family":"Kennelly","sequence":"first","affiliation":[{"name":"Department of Urology Carolinas Rehabilitation Charlotte North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Dmochowski","sequence":"additional","affiliation":[{"name":"Department of Urological Surgery Vanderbilt University Nashville Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinrich","family":"Schulte\u2010Baukloh","sequence":"additional","affiliation":[{"name":"Department of Urologic Surgery Medical School of Charit\u00e9 University Hospital Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Ethans","sequence":"additional","affiliation":[{"name":"University of Manitoba Winnipeg Manitoba Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Del Popolo","sequence":"additional","affiliation":[{"name":"Department of Neurourology Careggi University Hospital Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtenay","family":"Moore","sequence":"additional","affiliation":[{"name":"Glickman Urological Institute Cleveland Clinic Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda","family":"Jenkins","sequence":"additional","affiliation":[{"name":"Allergan, Inc. Irvine California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Guard","sequence":"additional","affiliation":[{"name":"Allergan, Ltd. Marlow United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zheng","sequence":"additional","affiliation":[{"name":"Allergan, Inc. Bridgewater New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Karsenty","sequence":"additional","affiliation":[{"name":"Department of Urology Aix\u2010Marseille Universit\u00e9 Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"On Behalf of 191622\u2010094 Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410X.1997.00191.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002060-200112000-00008"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458506075651"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2008.06.047"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.01.125"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2011.07.002"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2012.11.010"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(98)00454-3"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2007.02.009"},{"key":"e_1_2_7_11_1","first-page":"93","volume-title":"Therapy with botulinum toxin","author":"Hatheway CL","year":"1994"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23254"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.2165\/11597970-000000000-00000"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/21681805.2013.814707"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2014.113"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2012.174"}],"container-title":["Neurourology and Urodynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fnau.22934","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fnau.22934","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.22934","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T06:29:45Z","timestamp":1696400985000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/nau.22934"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,24]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["10.1002\/nau.22934"],"URL":"https:\/\/doi.org\/10.1002\/nau.22934","archive":["Portico"],"relation":{},"ISSN":["0733-2467","1520-6777"],"issn-type":[{"value":"0733-2467","type":"print"},{"value":"1520-6777","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,24]]}}}