{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:39:39Z","timestamp":1790109579280,"version":"4.0.1"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,12,29]],"date-time":"2015-12-29T00:00:00Z","timestamp":1451347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Astellas Pharma Europe BV"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>To investigate the effect on urodynamics of 4 weeks treatment with solifenacin succinate in patients with neurogenic detrusor overactivity (NDO) due to multiple sclerosis (MS) or spinal cord injury (SCI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>SONIC was a prospective, multicenter, double\u2010blind, phase 3b\/4 study investigating the efficacy and safety of solifenacin 10\u2009mg in patients with NDO due to MS or SCI. Patients (n\u2009=\u2009189) were randomized to placebo or active treatment (solifenacin 5\u2009mg, 10\u2009mg or oxybutynin hydrochloride 15\u2009mg) for 4 weeks, after a 2\u2010week, single\u2010blind, placebo run\u2010in period. The primary endpoint was change in maximum cystometric capacity (MCC) from baseline to end of treatment. The primary analysis compared solifenacin 10\u2009mg versus placebo; all other comparisons were considered secondary. Secondary endpoints included changes in urodynamic parameters, patient\u2010reported outcomes, and safety assessments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the primary analysis, solifenacin 10\u2009mg significantly improved mean change from baseline MCC versus placebo (<jats:italic>P\u2009<\/jats:italic>&lt;\u20090.001) and was associated with improvements in bladder volume at first contraction and at first leak as well as detrusor pressure at first leak. Similar results were obtained for oxybutynin versus placebo. Patient perception of bladder condition significantly improved with solifenacin 10\u2009mg versus placebo (<jats:italic>P\u2009<\/jats:italic>=\u20090.041). There was a clear improvement in quality of life (QoL) in the solifenacin arms versus placebo. The overall incidence of adverse events was low.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients with NDO due to MS and SCI, 4 weeks of treatment with solifenacin 10\u2009mg improved urodynamic variables and QoL versus placebo and was well tolerated. <jats:italic>Neurourol. Urodynam. 36:414\u2013421, 2017<\/jats:italic>. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.22945","type":"journal-article","created":{"date-parts":[[2015,12,29]],"date-time":"2015-12-29T22:08:39Z","timestamp":1451426919000},"page":"414-421","source":"Crossref","is-referenced-by-count":58,"title":["Solifenacin is effective and well tolerated in patients with neurogenic detrusor overactivity: Results from the double\u2010blind, randomized, active\u2010 and placebo\u2010controlled SONIC urodynamic study"],"prefix":"10.1002","volume":"36","author":[{"given":"G.","family":"Amarenco","sequence":"first","affiliation":[{"name":"H\u00f4pital Tenon Service De Neuro\u2010Urologie Et D'Explorations Perineales Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Sutory","sequence":"additional","affiliation":[{"name":"Urological Department of Traumatological Clinic Traumatological Hospital, School of Medicine, Masaryk 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