{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:26:56Z","timestamp":1791235616000,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,1,12]],"date-time":"2016-01-12T00:00:00Z","timestamp":1452556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate potential predictors of non\u2010response to treatment with 200U onabotulinum toxin A (onaBoNTA) in women with refractory detrusor overactivity (DO).<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>A secondary analysis of a randomized trial of 200U onaBoNTA versus placebo in women with refractory DO analyzed baseline and 6 week follow\u2010up data. Univariate and multivariate logistic regression were used to assess demographic factors and baseline clinical parameters on non\u2010response to treatment defined as 20% or less improvement in urinary urgency and leakage episodes, 10% or less in voiding frequency, not achieving continence, and \u201cno change\u201d or worse on PGI\u2010I score at 6 weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One Hundred and twenty\u2010two women were included. Twenty\u2010nine (23.8%), 24 (19.7%), and 19 (15.6%) were non\u2010responders to treatment for urgency, voiding, and leakage episodes, respectively. Fifty\u2010nine (48.4%) failed to achieve continence, and 28 (23%) were non\u2010responders on the PGI\u2010I scale. Smoking status (OR: 2.89 95%CI 1.08, 7.73, <jats:italic>P<\/jats:italic>\u2009=\u20090.034) predicted non\u2010response in urgency episodes, and higher baseline leakage episodes (OR: 1.17 95%CI 1.04, 1.31, <jats:italic>P<\/jats:italic>\u2009=\u20090.007) predicted non\u2010response in achieving continence. Increasing age (OR 1.04, 95%CI 1.0, 1.09, <jats:italic>P<\/jats:italic>\u2009=\u20090.063) and body mass index (BMI) (OR 1.07, 95%CI 1.0, 1.16, <jats:italic>P<\/jats:italic>\u2009=\u20090.065) showed marginal associations with non\u2010response on the PGI\u2010I scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>onaBoNTA is an effective treatment for refractory DO, but some fail to respond. For identification of women at risk, our data indicate smokers should be advised of a lesser chance of successful treatment. Older women, those with high BMI and with more severe leakage also have a higher risk of failure. <jats:italic>Neurourol. 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