{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T10:22:38Z","timestamp":1772965358572,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,1,15]],"date-time":"2016-01-15T00:00:00Z","timestamp":1452816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>To evaluate the feasibility and reliability of current perception threshold (CPT) measurement for sensory assessment of distinct locations in the male lower urinary tract (LUT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twelve male subjects (&gt;18 years) without LUT symptoms or medical comorbidities were eligible. CPTs were determined twice (interval: 7\u201320 days) at the bladder dome, trigone and the proximal, membranous, and distal urethra. Square wave electrical stimulation of 3\u2009Hz\/0.2\u2009ms and 0.5\u2009Hz\/1\u2009ms was applied using a transurethral 8F catheter placed under fluoroscopic control. Bladder volume was kept constant (60\u2009mL) using a second 10F catheter. Repetitive measurements and reliability were assessed by analysis of variance (ANOVA) and intraclass correlation coefficient (ICC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The ANOVA revealed significant main effects for stimulation site (<jats:italic>P<\/jats:italic>\u2009=\u20090.008) and type of stimulation (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) with lower CPTs for 0.5\u2009Hz\/1\u2009ms compared to 3\u2009Hz\/0.2\u2009ms. There was no significant effect for visit number (<jats:italic>P<\/jats:italic>\u2009=\u20090.061). CPTs were higher for bladder dome than for proximal (0.5\u2009Hz\/1\u2009ms: <jats:italic>P<\/jats:italic>\u2009=\u20090.022; 3\u2009Hz\/0.2\u2009ms: <jats:italic>P<\/jats:italic>\u2009=\u20090.022) and distal urethra (0.5\u2009Hz\/1\u2009ms: <jats:italic>P<\/jats:italic>\u2009=\u20090.026; 3\u2009Hz\/0.2\u2009ms: <jats:italic>P<\/jats:italic>\u2009=\u20090.030). Reliability of CPT measurements was excellent to good (ICC\u2009=\u20090.67\u20130.96) except for the bladder dome (5\u2009Hz\/1\u2009ms: ICC\u2009=\u20090.45; 3\u2009Hz\/0.2\u2009ms: ICC\u2009=\u20090.20) and distal urethra (3\u2009Hz\/0.2\u2009ms: ICC\u2009=\u20090.57).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CPTs can be reliably detected at different LUT locations. However, alert and compliant subjects are essential. CPTs of LUT may become a complementary assessment method providing information on responsiveness and sensitivity of afferent LUT nerves. This is especially relevant for urethral afferents, which are not covered by standard urodynamic investigations. <jats:italic>Neurourol. Urodynam. 36:469\u2013473, 2017<\/jats:italic>. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.22956","type":"journal-article","created":{"date-parts":[[2016,1,16]],"date-time":"2016-01-16T18:11:05Z","timestamp":1452967865000},"page":"469-473","source":"Crossref","is-referenced-by-count":10,"title":["Sensory function assessment of the human male lower urinary tract using current perception thresholds"],"prefix":"10.1002","volume":"36","author":[{"given":"Stephanie C.","family":"Kn\u00fcpfer","sequence":"first","affiliation":[{"name":"Department of Neuro\u2010Urology Spinal Cord Injury Center and Research Balgrist University Hospital University of Z\u00fcrich Z\u00fcrich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina D.","family":"Liechti","sequence":"additional","affiliation":[{"name":"Department of Neuro\u2010Urology Spinal Cord Injury Center and Research Balgrist University Hospital University of Z\u00fcrich Z\u00fcrich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flavia","family":"Gregorini","sequence":"additional","affiliation":[{"name":"Department of Neuro\u2010Urology Spinal Cord Injury Center and Research Balgrist University Hospital University of Z\u00fcrich Z\u00fcrich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"De Wachter","sequence":"additional","affiliation":[{"name":"Department of Urology Antwerp University Hospital and Faculty of Medicine University of Antwerp Antwerp Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas M.","family":"Kessler","sequence":"additional","affiliation":[{"name":"Department of Neuro\u2010Urology Spinal Cord Injury Center and Research Balgrist University Hospital University of Z\u00fcrich Z\u00fcrich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"Mehnert","sequence":"additional","affiliation":[{"name":"Department of Neuro\u2010Urology Spinal Cord Injury Center and Research Balgrist University Hospital University of Z\u00fcrich Z\u00fcrich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,1,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(02)01544-3"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOU.0b013e3283476ea2"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2007.08.043"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(01)00914-1"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000473599"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)65604-0"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.13066"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20095"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006903507321"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(199702)20:2<198::AID-MUS10>3.0.CO;2-#"},{"key":"e_1_2_7_12_1","unstructured":"(BAG) TFAotSCBfG. The Federal Authorities of the Swiss Confederation Bundesamt f\u00fcr Gesundheit (BAG). Diagnostische Referenzwerte (DRW) in der Projektionsradiologie [http:\/\/www.bag.admin.ch\/themen\/strahlung\/10463\/10958\/]. 2011."},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.11.151"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001360305"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)61908-6"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2005.03.016"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(01)00914-1"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2009.08377.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.12.060"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2008.03.016"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2012.196"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.10017"}],"container-title":["Neurourology and Urodynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fnau.22956","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fnau.22956","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.22956","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T06:29:50Z","timestamp":1696400990000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/nau.22956"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,15]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["10.1002\/nau.22956"],"URL":"https:\/\/doi.org\/10.1002\/nau.22956","archive":["Portico"],"relation":{},"ISSN":["0733-2467","1520-6777"],"issn-type":[{"value":"0733-2467","type":"print"},{"value":"1520-6777","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,15]]}}}