{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:00:52Z","timestamp":1787504452910,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,2,24]],"date-time":"2016-02-24T00:00:00Z","timestamp":1456272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Science Centre (Poland)","award":["2011\/01\/D\/NZ7\/0470"],"award-info":[{"award-number":["2011\/01\/D\/NZ7\/0470"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Despite the efficacy of intravesical onabotulinumtoxinA (Botox) therapy for urgency, urgency incontinence, and daytime frequency, its value in treatment of nocturia remains unclear. The aim of the prospective observational study was to assess the effect of onabotulinumtoxinA on night\u2010time symptoms in women with overactive bladder (OAB), including nocturia, night\u2010time urgency incontinence, and nocturnal voided volume as end\u2010points.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Women with idiopathic OAB (with at least one episode of urgency urinary incontinence (UUI) per day, \u22658 micturitions per 24\u2009hr, and \u22652 nocturia episodes per night) were enrolled. Patients with nocturnal polyuria were excluded. Botox (100\u2009U) was administered in 20 intra\u2010detrusor injections. Post\u2010void residual volumes (PVR) were checked at 2, 4, and 12\u2009weeks. Participants completed a 3\u2010day bladder diary and the King's Health Questionnaire (KHQ) before and 12 weeks after treatment, and reported the efficacy of the treatment on visual analog scale (VAS) at the final follow\u2010up visit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seventy\u2010six women completed the study. Botox injections were effective in the reduction of nocturia episodes (mean \u22120.98;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) and night\u2010time UUI episodes (\u22120.37;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) compared to the baseline. The increase of mean voided volume of the night\u2010time micturitions was 92.6\u2009ml (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). Patients reported a mean 58 points of improvement on the VAS. Urinary retention, which required self\u2010catheterization, was observed in three patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Intravesical Botox injection provides significant benefit for night\u2010time symptoms in OAB patients. Our results are applicable for women without nocturnal polyuria, and should prove useful when counseling patients about the risks and benefits of Botox.\n                      <jats:italic>Neurourol. Urodynam. 36:648\u2013652, 2017<\/jats:italic>\n                      . \u00a9 2016 Wiley Periodicals, Inc.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/nau.22983","type":"journal-article","created":{"date-parts":[[2016,2,26]],"date-time":"2016-02-26T03:22:08Z","timestamp":1456456928000},"page":"648-652","source":"Crossref","is-referenced-by-count":14,"title":["Can botox improve night\u2010time overactive bladder symptoms in women?"],"prefix":"10.1002","volume":"36","author":[{"given":"Pawel","family":"Miotla","sequence":"first","affiliation":[{"name":"Department of Gynaecology Medical University of Lublin Lublin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rufus","family":"Cartwright","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Department of Urogynaecology Imperial College London London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konrad","family":"Futyma","sequence":"additional","affiliation":[{"name":"Department of Gynaecology Medical University of Lublin Lublin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Bogusiewicz","sequence":"additional","affiliation":[{"name":"Department of Gynaecology Medical University of Lublin Lublin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Skorupska","sequence":"additional","affiliation":[{"name":"Department of Gynaecology Medical University of Lublin Lublin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izabela","family":"Winkler","sequence":"additional","affiliation":[{"name":"Department of Gynaecology Medical University of Lublin Lublin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Rechberger","sequence":"additional","affiliation":[{"name":"Department of Gynaecology Medical University of Lublin Lublin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,2,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2014.01.019"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20737"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.10053"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2012.05.016"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20022"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2009.03.080"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.22663"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.22595"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2011.05.083"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.10.043"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.12753"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2014.09.024"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.5489\/cuaj.3097"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-15-0654"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.22936"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2015.01.087"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.17772\/gp\/1716"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.08.060"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.12.022"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.12443"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2013.04.001"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.22645"},{"key":"e_1_2_6_24_1","article-title":"Effectiveness of botulinum toxin injection in the treatment of de novo OAB symptoms following midurethral sling surgery","author":"Miotla P","year":"2015","journal-title":"Int Urogynecol J"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.22598"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.22925"}],"container-title":["Neurourology and Urodynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fnau.22983","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fnau.22983","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.22983","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T14:11:08Z","timestamp":1696342268000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/nau.22983"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,24]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.1002\/nau.22983"],"URL":"https:\/\/doi.org\/10.1002\/nau.22983","archive":["Portico"],"relation":{},"ISSN":["0733-2467","1520-6777"],"issn-type":[{"value":"0733-2467","type":"print"},{"value":"1520-6777","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,24]]}}}