{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T06:48:47Z","timestamp":1780382927950,"version":"3.54.1"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,3,29]],"date-time":"2016-03-29T00:00:00Z","timestamp":1459209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>To evaluate the correlation between symptom severity of bladder pain syndrome\/interstitial cystitis (BPS\/IC) and autonomic nervous system activity, we examined autonomic responses during bladder hydrodistention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Medical records were collected from a prospective database for patients who underwent bladder hydrodistention with a fixed protocol from March 2012 to December 2013. A total of 40 patients (16 males, 24 females) were included for the analysis. Hydrodistention was performed under general anesthesia (31 patients), spinal anesthesia (six patients), and both types of anesthesia (three patients) at different times. Twenty\u2010five patients who underwent holmium laser enucleation of the prostate served as controls. Pulse rate (PR), systolic (SBP), and diastolic blood pressure (BP) were measured pre\u2010hydrodistention, during hydrodistention, and after drainage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The spinal anesthesia and control groups exhibited little change in BP and PR during hydrodistention, while a significant increase was demonstrated in the general anesthesia group (e.g., \u0394SBP 4.89\u2009\u00b1\u20094.80, 10.40\u2009\u00b1\u200919.03, and 56.26\u2009\u00b1\u200930.38\u2009mm Hg, respectively, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Under general anesthesia, autonomic response during hydrodistention was more prominent in patients with preoperative visual analogue scale (VAS) pain score \u22657, Hunner's lesion, and glomerulation grade 4. Preoperative maximal cystometric capacity negatively correlated with changes in SBP during hydrodistention (R<jats:sup>2<\/jats:sup>\u2009=\u20090.294, <jats:italic>P<\/jats:italic>\u2009=\u20090.009), while VAS score and interstitial cystitis problem index demonstrated a positive correlation with the changes (R<jats:sup>2<\/jats:sup>\u2009=\u20090.208, <jats:italic>P<\/jats:italic>\u2009=\u20090.012; R<jats:sup>2<\/jats:sup>\u2009=\u20090.173, <jats:italic>P<\/jats:italic>\u2009=\u20090.015).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Under general anesthesia, exaggerated autonomic responses to bladder hydrodistention were demonstrated in BPS\/IC patients, which reflected the severity of symptoms. These results support the hypothesis of altered activity of autonomic system in BPS\/IC. <jats:italic>Neurourol. Urodynam. 36:677\u2013682, 2017<\/jats:italic>. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.22994","type":"journal-article","created":{"date-parts":[[2016,3,30]],"date-time":"2016-03-30T23:25:35Z","timestamp":1459380335000},"page":"677-682","source":"Crossref","is-referenced-by-count":8,"title":["Autonomic response during bladder hydrodistention reflects the severity of symptoms in patients with bladder pain syndrome\/interstitial cystitis"],"prefix":"10.1002","volume":"36","author":[{"given":"Sang Woon","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Urology, Urological Science Institute Yonsei University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee Seo","family":"Son","sequence":"additional","affiliation":[{"name":"Department of Urology, Urological Science Institute Yonsei University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irela Soto","family":"Troya","sequence":"additional","affiliation":[{"name":"Department of Urology, Urological Science Institute Yonsei University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Yu","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Urology, Urological Science Institute Yonsei University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myoung Joo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Urology, Urological Science Institute Yonsei University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew O.","family":"Fraser","sequence":"additional","affiliation":[{"name":"Veterans Affairs Medical Center Durham North Carolina"},{"name":"Department of Surgery Duke University Medical Center Durham North Carolina"},{"name":"Institute for Medical Research Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jang Hwan","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Urology, Urological Science Institute Yonsei University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005392-199803000-00145"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000132150.45909.d2"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(98)00663-3"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2015.04.101"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.02.2561"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2007.09.019"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1682\/JRRD.2006.05.0051"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2003.11.021"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/end.1998.12.457"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/981419"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)37314-7"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-014-0243-0"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.22542"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2013.12.011"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0000000000000089"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(03)00557-X"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.160.9.1554"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4530(99)00035-9"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2014.05.029"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(01)01098-6"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2005.03.015"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.14.5.511"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1982.sp014061"},{"key":"e_1_2_7_25_1","first-page":"R132","article-title":"Effects of capsaicin on micturition and associated reflexes in rats","volume":"265","author":"Cheng CL","year":"1993","journal-title":"Am J Physiol"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2001.281.4.R1302"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-199512001-00003"}],"container-title":["Neurourology and Urodynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fnau.22994","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fnau.22994","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.22994","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T18:10:37Z","timestamp":1696356637000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/nau.22994"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,29]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.1002\/nau.22994"],"URL":"https:\/\/doi.org\/10.1002\/nau.22994","archive":["Portico"],"relation":{},"ISSN":["0733-2467","1520-6777"],"issn-type":[{"value":"0733-2467","type":"print"},{"value":"1520-6777","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,29]]}}}