{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T20:32:47Z","timestamp":1774038767724,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,4,6]],"date-time":"2016-04-06T00:00:00Z","timestamp":1459900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>We evaluated long\u2010term efficacy and safety of a combination therapy (CT) with an anticholinergic agent and an \u03b11\u2010blocker for patients with benign prostatic enlargement (BPE) complaining of voiding and overactive bladder (OAB) symptoms, in comparison with those of \u03b11\u2010blocker monotherapy (MT), by conducting a urodynamic study (UDS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a randomized prospective study involving 120 outpatients with untreated BPE associated with urinary urgency at least once per week and OABSS of \u22653. The patients were randomly assigned to receive MT with silodosin at 8\u2009mg\/day or CT with silodosin at 8\u2009mg\/day and propiverine at 20\u2009mg\/day. Changes in parameters from baseline to 12 weeks and 1 year after administration were assessed based on IPSS, IPSS\u2010QOL, OABSS, and voiding and storage functions as measured by UDS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In efficacy analysis, 53 patients with MT and 51 with CT were included. Although mean IPSS and OABSS significantly improved in both groups, the CT group showed statistically significant improvement in OABSS (\u22123.4 in CT, \u22122.4 in MT, <jats:italic>P<\/jats:italic>\u2009=\u20090.04), IPSS\u2010QOL (\u22121.9, \u22121.2, <jats:italic>P<\/jats:italic>\u2009=\u20090.01), and OAB\u2010urgency score (\u22121.8, \u22121.2, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01) at the long\u2010term evaluation. In storage function, both groups showed significant improvements, but the CT group demonstrated a greater improvement in terms of disappearance rate of detrusor overactivity (54.5% in CT, 34.2% in MT, <jats:italic>P<\/jats:italic>\u2009=\u20090.07) and bladder capacity (+61\u2009mL, +33\u2009mL, <jats:italic>P<\/jats:italic>\u2009=\u20090.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Long\u2010term combination treatment with silodosin and propiverine was effective and safe for BPE patients with voiding and OAB symptoms. <jats:italic>Neurourol. Urodynam. 36:748\u2013754, 2017<\/jats:italic>. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.23013","type":"journal-article","created":{"date-parts":[[2016,4,10]],"date-time":"2016-04-10T16:02:43Z","timestamp":1460304163000},"page":"748-754","source":"Crossref","is-referenced-by-count":17,"title":["Long\u2010term efficacy of a combination therapy with an anticholinergic agent and an \u03b11\u2010blocker for patients with benign prostatic enlargement complaining both voiding and overactive bladder symptoms: A randomized, prospective, comparative trial using a urodynamic study"],"prefix":"10.1002","volume":"36","author":[{"given":"Yoshihisa","family":"Matsukawa","sequence":"first","affiliation":[{"name":"Department of Urology Nagoya University Graduate School of Medicine Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shun","family":"Takai","sequence":"additional","affiliation":[{"name":"Department of Urology Nagoya University Graduate School of Medicine Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhito","family":"Funahashi","sequence":"additional","affiliation":[{"name":"Department of Urology Nagoya University Graduate School of Medicine Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Urology Nagoya University Graduate School of Medicine Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tokunori","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Urology Nagoya University Graduate School of Medicine Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Momokazu","family":"Gotoh","sequence":"additional","affiliation":[{"name":"Department of Urology Nagoya University Graduate School of Medicine Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,4,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.1994.tb09181.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-005-3232-x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(01)01506-0"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365590600830862"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)65075-4"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.2008.02177.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.22286"},{"key":"e_1_2_8_9_1","unstructured":"American Urological Association Education and Research Inc. 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