{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T13:12:31Z","timestamp":1789909951589,"version":"4.0.1"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec><jats:title>Context<\/jats:title><jats:p>Bladder management in spina bifida patients relies on clean intermittent catheterization and oral antimuscarinics with a significant failure rate. The efficacy of intradetrusor injections of botulinum toxin has been confirmed in patients with spinal cord injury or multiple sclerosis but not in patients with myelomeningocele.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To conduct a systematic review of current evidence regarding the efficacy of intra\u2010detrusor injections of Botulinum Toxin A (BTX\u2010A) in spina bifida patients with neurogenic detrusor overactivity (NDO) refractory to antimuscarinics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A research has been conducted on Medline and Embase using the keywords: (\u201cspina bifida\u201d OR \u201cmyelomeningocele\u201d OR \u201cdysraphism\u201d) AND \u201ctoxin.\u201d The search strategy and studies selection were performed using the PICOS method according to the PRISMA statement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>Twelve published series were included (n\u2009=\u2009293 patients). All patients were &lt;18 years old. There was no randomized study comparing BTX\u2010A versus placebo and most studies had no control group. Most studies reported a clinical and urodynamic improvement with resolution of incontinence in 32\u2013100% of patients, a decrease in maximum detrusor pressure from 32 to 54%, an increase of maximum cystometric capacity from 27 to 162%, and an improvement in bladder compliance of 28\u2013176%. Two studies suggested lower efficacy in patients with low compliance bladder compared to those with isolated detrusor overactivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Intradetrusor injections of BTX\u2010A could be effective in children with spina bifida but this assumption is not supported by high level of evidence studies. There is no data available in adult patients. <jats:italic>Neurourol. Urodynam. 36:557\u2013564, 2017<\/jats:italic>. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.23025","type":"journal-article","created":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T11:16:53Z","timestamp":1463483813000},"page":"557-564","source":"Crossref","is-referenced-by-count":46,"title":["Outcomes of intra\u2010detrusor injections of botulinum toxin in patients with spina bifida: A systematic review"],"prefix":"10.1002","volume":"36","author":[{"given":"Juliette","family":"Hascoet","sequence":"first","affiliation":[{"name":"Service de chirurgie p\u00e9diatrique CHU Rennes Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Manunta","sequence":"additional","affiliation":[{"name":"Service d'urologie CHU Rennes Rennes France"},{"name":"Centre de r\u00e9f\u00e9rence spina bifida CHU Rennes Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charl\u00e8ne","family":"Brochard","sequence":"additional","affiliation":[{"name":"Centre de r\u00e9f\u00e9rence spina bifida CHU Rennes Rennes France"},{"name":"Service de Gastro\u2010Ent\u00e9rologie CHU Rennes Rennes France"},{"name":"Equipe th\u00e9matique INPHY CIC 1414 et INSERM UMR 991 CHU Rennes Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Arnaud","sequence":"additional","affiliation":[{"name":"Service de chirurgie p\u00e9diatrique CHU Rennes Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mireille","family":"Damphousse","sequence":"additional","affiliation":[{"name":"Centre de r\u00e9f\u00e9rence spina bifida CHU Rennes Rennes France"},{"name":"Service de m\u00e9decine physique et r\u00e9adaptation CHU Rennes Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Menard","sequence":"additional","affiliation":[{"name":"Centre de r\u00e9f\u00e9rence spina bifida CHU Rennes Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Kerdraon","sequence":"additional","affiliation":[{"name":"Centre de r\u00e9f\u00e9rence spina bifida CHU Rennes Rennes France"},{"name":"Centre de r\u00e9\u00e9ducation de Kerpape Ploemeur France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert","family":"Journel","sequence":"additional","affiliation":[{"name":"Centre de r\u00e9f\u00e9rence spina bifida CHU Rennes Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Bonan","sequence":"additional","affiliation":[{"name":"Centre de r\u00e9f\u00e9rence spina bifida CHU Rennes Rennes France"},{"name":"Service de m\u00e9decine physique et r\u00e9adaptation CHU Rennes Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Odent","sequence":"additional","affiliation":[{"name":"Centre de r\u00e9f\u00e9rence spina bifida CHU Rennes Rennes France"},{"name":"Service de g\u00e9n\u00e9tique CHU Rennes Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Fremond","sequence":"additional","affiliation":[{"name":"Service de chirurgie p\u00e9diatrique CHU Rennes Rennes France"},{"name":"Centre de r\u00e9f\u00e9rence spina bifida CHU Rennes Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Siproudhis","sequence":"additional","affiliation":[{"name":"Centre de r\u00e9f\u00e9rence spina bifida CHU Rennes Rennes France"},{"name":"Service de Gastro\u2010Ent\u00e9rologie CHU Rennes Rennes France"},{"name":"Equipe th\u00e9matique INPHY CIC 1414 et INSERM UMR 991 CHU Rennes Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Gam\u00e9","sequence":"additional","affiliation":[{"name":"D\u00e9partement d'Urologie Transplantation R\u00e9nale et Andrologie CHU Rangueil Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit","family":"Peyronnet","sequence":"additional","affiliation":[{"name":"Service d'urologie CHU Rennes Rennes France"},{"name":"Centre de r\u00e9f\u00e9rence spina bifida CHU Rennes Rennes France"},{"name":"Equipe th\u00e9matique INPHY CIC 1414 et INSERM UMR 991 CHU Rennes Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"For the French Referral Network of Spina Bifida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17445-X"},{"key":"e_1_2_6_3_1","unstructured":"20_Neurogenic\u2010LUTD_LR.pdf [Internet]. [cited 2015 Oct 12]. Available from:http:\/\/uroweb.org\/wp\u2010content\/uploads\/20_Neurogenic\u2010LUTD_LR.pdf"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)67283-7"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.purol.2013.09.020"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2011.07.002"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.01.125"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000100"},{"key":"e_1_2_6_9_1","unstructured":"Cochrane Handbook for Systematic Reviews of Interventions [Internet]. [cited 2015 Oct 20]. Available from:http:\/\/handbook.cochrane.org"},{"key":"e_1_2_6_10_1","unstructured":"HowickJ ChalmersI GlasziouP et al. Explanation of the 2011 Oxford Centre for Evidence\u2010Based Medicine (OCEBM) levels of evidence (background document). OCEBM Web site.http:\/\/www.cebm.net\/index.aspx?o=5653"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2014.08.009"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.4111\/kju.2014.55.4.281"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins5010016"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.5173\/ceju.2012.03.art12"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.21124"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2009.09.087"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2010.01.058"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.2009.05129.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2006.05.056"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)00400-3"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000108892.35041.2d"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(01)01641-7"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2009.01.005"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddrr.99"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000086559"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2014.12.019"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2014.03.041"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2015.99"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.22376"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-6777(1999)18:2<139::AID-NAU9>3.0.CO;2-U"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)67730-0"},{"key":"e_1_2_6_32_1","article-title":"Preliminary results of botulinum toxin A switch after first detrusor injection failure as a treatment of neurogenic detrusor overactivity","author":"Peyronnet B","year":"2014","journal-title":"Neurourol Urodyn"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.purol.2015.07.006"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.22630"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2011.10.028"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2010.08.021"}],"container-title":["Neurourology and Urodynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fnau.23025","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fnau.23025","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.23025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T14:12:05Z","timestamp":1696342325000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/nau.23025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,17]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.1002\/nau.23025"],"URL":"https:\/\/doi.org\/10.1002\/nau.23025","archive":["Portico"],"relation":{},"ISSN":["0733-2467","1520-6777"],"issn-type":[{"value":"0733-2467","type":"print"},{"value":"1520-6777","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,17]]}}}