{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T04:14:03Z","timestamp":1790050443213,"version":"4.0.1"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,6,27]],"date-time":"2016-06-27T00:00:00Z","timestamp":1466985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Astellas Pharma Inc"},{"name":"CREST-AMED"},{"name":"KAKENHI on innovative Areas","award":["25117003"],"award-info":[{"award-number":["25117003"]}]},{"name":"Challenging Exploratory Research","award":["15K15524"],"award-info":[{"award-number":["15K15524"]}]},{"name":"Challenging Exploratory Research","award":["26670699"],"award-info":[{"award-number":["26670699"]}]},{"name":"Scientific Research","award":["23390381"],"award-info":[{"award-number":["23390381"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>The pathophysiologies of nocturia (NOC) and nocturnal polyuria (NP) are multifactorial and their etiologies remain unclear in a large number of patients. Clock genes exist in most cells and organs, and the products of <jats:italic>Clock<\/jats:italic> regulate circadian rhythms as representative clock genes. Clock genes regulate lower urinary tract function, and a newly suggested concept is that abnormalities in clock genes cause lower urinary tract symptoms. In the present study, we investigated the voiding behavior of <jats:italic>Clock<\/jats:italic> mutant (<jats:italic>Clock<jats:sup>\u039419\/\u039419<\/jats:sup><\/jats:italic>) mice in order to determine the effects of clock genes on NOC\/NP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Male C57BL\/6 mice aged 8\u201312 weeks (WT) and male C57BL\/6 <jats:italic>Clock<jats:sup>\u039419\/\u039419<\/jats:sup><\/jats:italic> mice aged 8 weeks were used. They were bred under 12\u2009hr light\/dark conditions for 2 weeks and voiding behavior was investigated by measuring water intake volume, urine volume, urine volume\/void, and voiding frequency in metabolic cages in the dark and light periods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No significant differences were observed in behavior patterns between <jats:italic>Clock<jats:sup>\u039419\/\u039419<\/jats:sup><\/jats:italic> and WT mice. <jats:italic>Clock<jats:sup>\u039419\/\u039419<\/jats:sup><\/jats:italic> mice showed greater voiding frequencies and urine volumes during the sleep phase than WT mice. The diurnal change in urine volume\/void between the dark and light periods in WT mice was absent in <jats:italic>Clock<jats:sup>\u039419\/\u039419<\/jats:sup><\/jats:italic> mice. Additionally, functional bladder capacity was significantly lower in <jats:italic>Clock<\/jats:italic><jats:sup>\u039419\/\u039419<\/jats:sup> mice than in WT mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We demonstrated that <jats:italic>Clock<jats:sup>\u039419\/\u039419<\/jats:sup><\/jats:italic> mice showed the phenotype of NOC\/NP. The <jats:italic>Clock<jats:sup>\u039419\/\u039419<\/jats:sup><\/jats:italic> mouse may be used as an animal model of NOC and NP. <jats:italic>Neurourol. Urodynam. 36:1034\u20131038, 2017<\/jats:italic>. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.23062","type":"journal-article","created":{"date-parts":[[2016,6,27]],"date-time":"2016-06-27T18:11:42Z","timestamp":1467051102000},"page":"1034-1038","source":"Crossref","is-referenced-by-count":24,"title":["The <i>Clock<\/i> mutant mouse is a novel experimental model for nocturia and nocturnal polyuria"],"prefix":"10.1002","volume":"36","author":[{"given":"Tatsuya","family":"Ihara","sequence":"first","affiliation":[{"name":"Department of Urology, Interdisciplinary Graduate School of Medicine University of Yamanashi Chuo Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiko","family":"Mitsui","sequence":"additional","affiliation":[{"name":"Department of Urology, Interdisciplinary Graduate School of Medicine University of Yamanashi Chuo Yamanashi 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