{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:08:22Z","timestamp":1792782502989,"version":"4.5.0"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,9,21]],"date-time":"2016-09-21T00:00:00Z","timestamp":1474416000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"This study was sponsored by IBSA Farmaceutici Italia. This assistance was funded by IBSA Institut Biochimique SA","id":[{"id":"https:\/\/ror.org\/02cf8gj49","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:sec>\n                    <jats:title>AIMS<\/jats:title>\n                    <jats:p>\n                      Intravesical instillation of hyaluronic acid (HA) plus chondroitin sulfate (CS) in women with bladder pain syndrome\/interstitial cystitis (BPS\/IC) has shown promising results. This study compared the efficacy, safety, and costs of intravesical HA\/CS (Ialuril\n                      <jats:sup>\u00ae<\/jats:sup>\n                      , IBSA) to dimethyl sulfoxide (DMSO).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Randomized, open\u2010label, multicenter study involving 110 women with BPS\/IC. The allocation ratio (HA\/CS:DMSO) was 2:1. Thirteen weekly instillations of HA (1.6%)\/CS (2.0%) or 50% DMSO were given. Patients were evaluated at 3 (end\u2010of\u2010treatment) and 6 months. Primary endpoint was reduction in pain intensity at 6 months by visual analogue scale (VAS) versus baseline. Secondary efficacy measurements were quality of life and economic analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      A significant reduction in pain intensity was observed at 6 months in both treatment groups versus baseline (\n                      <jats:italic>P\u2009<\/jats:italic>\n                      &lt;\u20090.0001) in the intention\u2010to\u2010treat population. Treatment with HA\/CS resulted in a greater reduction in pain intensity at 6 months compared with DMSO for the per\u2010protocol population (mean VAS reduction 44.77\u2009\u00b1\u200925.07 vs. 28.89\u2009\u00b1\u200931.14, respectively;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.0186). There were no significant differences between treatment groups in secondary outcomes. At least one adverse event was reported in 14.86% and 30.56% of patients in the HA\/CS and DMSO groups, respectively. There were significantly fewer treatment\u2010related adverse events for HA\/CS versus DMSO (1.35% vs. 22.22%;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.001). Considering direct healthcare costs, the incremental cost\u2010effectiveness ratio of HA\/CS versus DMSO fell between 3735\u20ac\/quality\u2010adjusted life years (QALY) and 8003\u20ac\/QALY.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Treatment with HA\/CS appears to be as effective as DMSO with a potentially more favorable safety profile. Both treatments increased health\u2010related quality of life, while HA\/CS showed a more acceptable cost\u2010effectiveness profile.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/nau.23091","type":"journal-article","created":{"date-parts":[[2016,9,21]],"date-time":"2016-09-21T11:36:40Z","timestamp":1474457800000},"page":"1178-1186","source":"Crossref","is-referenced-by-count":59,"title":["A randomized, open\u2010label, multicenter study of the efficacy and safety of intravesical hyaluronic acid and chondroitin sulfate versus dimethyl sulfoxide in women with bladder pain syndrome\/interstitial cystitis"],"prefix":"10.1002","volume":"36","author":[{"given":"Mauro","family":"Cervigni","sequence":"first","affiliation":[{"name":"Catholic University Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Sommariva","sequence":"additional","affiliation":[{"name":"G. Fornaroli Hospital Magenta (MI) Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Tenaglia","sequence":"additional","affiliation":[{"name":"SS. Annunziata Hospital Chieti\u2010Pescara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Porru","sequence":"additional","affiliation":[{"name":"IRCCS, San Matteo Hospital Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edoardo","family":"Ostardo","sequence":"additional","affiliation":[{"name":"S. Maria degli Angeli Hospital Pordenone Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Giamm\u00f2","sequence":"additional","affiliation":[{"name":"CTO\u2010Maria Adelaide Hospital Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Trevisan","sequence":"additional","affiliation":[{"name":"R&amp;D Department IBSA Institut Biochimique SA Pambio\u2010Noranco Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Frangione","sequence":"additional","affiliation":[{"name":"R&amp;D Department IBSA Institut Biochimique SA Pambio\u2010Noranco Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oriana","family":"Ciani","sequence":"additional","affiliation":[{"name":"CeRGAS Bocconi Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosanna","family":"Tarricone","sequence":"additional","affiliation":[{"name":"CeRGAS Bocconi Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni L.","family":"Pappagallo","sequence":"additional","affiliation":[{"name":"Medical Oncology Department Mirano Hospital Mirano (VE) Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,9,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2003.10.034"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpuro0385"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2010.10.016"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.4292"},{"key":"e_1_2_8_6_1","first-page":"83","article-title":"Treating interstitial cystitis\/bladder pain syndrome as a chronic disease","volume":"16","author":"Bosch PC","year":"2014","journal-title":"Rev Urol"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2011.07.069"},{"key":"e_1_2_8_8_1","first-page":"405","article-title":"Bladder pain syndrome\/interstitial cystitis: a reappraisal for the clinician","volume":"56","author":"Mahmoud MS","year":"2011","journal-title":"J Reprod Med"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-015-0504-9"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2007.03.020"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11934-010-0141-5"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-012-1742-y"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-008-0572-4"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2004.10.022"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365590410015876-1"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)65933-0"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000283012"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756287213490052"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.2174\/157488708784223817"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2007.09.019"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(99)80333-1"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2007.06.1089"},{"key":"e_1_2_8_23_1","unstructured":"Urology EAo. 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