{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T14:58:49Z","timestamp":1761663529612},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,10,29]],"date-time":"2016-10-29T00:00:00Z","timestamp":1477699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001868","name":"National Science Council of Taiwan","doi-asserted-by":"publisher","award":["NSC102\u20102314\u2010B\u2010182A\u2010091\u2010MY3"],"award-info":[{"award-number":["NSC102\u20102314\u2010B\u2010182A\u2010091\u2010MY3"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004606","name":"Chang Gung Medical Foundation","doi-asserted-by":"publisher","award":["CMRPG6E0241\u20102"],"award-info":[{"award-number":["CMRPG6E0241\u20102"]}],"id":[{"id":"10.13039\/501100004606","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Partial bladder outlet obstruction (PBOO) causes tissue inflammation, a significant increase in markers of systemic oxidative stress, and proliferation of circulating myeloid\u2010derived suppressor cells. Here, we investigated the regulatory mechanisms underlying inflammation and helper T cell involvement in PBOO.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Surgical PBOO was performed in four groups of rats: control (C), obstruction at 2 (O2) and 4 (O4) weeks, and 4 weeks after the relief of PBOO (R4) (<jats:italic>n<\/jats:italic>\u2009=\u20096 each). The urinary levels of prostaglandin E metabolite (PGEM), expression of inflammatory cytokines (IL\u20106 and IL\u201017) in the bladder, numbers of peripheral blood regulatory T cells (Treg cells), and levels of TGF\u2010\u03b21 were assessed via immunohistochemistry, flow cytometry, or ELISA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The levels of urinary PGEM, bladder IL\u201017, and TGF\u2010\u03b21 and the numbers of peripheral Treg cells (Foxp3) were all significantly increased at 2 and 4 weeks after PBOO. PGEM, IL\u201017, and Treg cells (Foxp3) were decreased after the relief of PBOO, while the levels of TGF\u2010\u03b21 continued to increase.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Transient PBOO triggers an acute, reversible increase in inflammatory cytokines and Treg cells. The distinct dynamics of individual inflammatory markers support their potential use as markers for monitoring bladder inflammation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.23136","type":"journal-article","created":{"date-parts":[[2016,10,29]],"date-time":"2016-10-29T09:36:42Z","timestamp":1477733802000},"page":"1306-1312","source":"Crossref","is-referenced-by-count":9,"title":["The relevance of immune responses to partial bladder outlet obstruction and reversal"],"prefix":"10.1002","volume":"36","author":[{"given":"Wei\u2010Yu","family":"Lin","sequence":"first","affiliation":[{"name":"Division of Urology Department of Surgery Chang Gung Memorial Hospital Chiayi Taiwan"},{"name":"Chang Gung University of Science and Technology Chiayi Taiwan"},{"name":"Chang Gung University Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Pai","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Urology Department of Surgery Chang Gung 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