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Recent publications use some correlation of lack of efficacy and or experienced side effects to define drug resistance. Algorithms based upon these definitions largely relate to the appropriate use of neuromodulation or botulinum neurotoxin, based upon patient selection and patient choice. Current treatment pathways are hampered by inability to consistently profile patients to optimize management, particularly after failure of initial pragmatic treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Further research is recommended to better identify patient phenotype for purposes of directing optimized therapy for OAB\/DO. Current treatment algorithms are influenced by extensive data generated from recent neuromodulation and botulinum neurotoxin trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/nau.23170","type":"journal-article","created":{"date-parts":[[2017,4,26]],"date-time":"2017-04-26T03:14:31Z","timestamp":1493176471000},"page":"882-893","source":"Crossref","is-referenced-by-count":49,"title":["Can we create a valid treatment algorithm for patients with drug resistant overactive bladder (OAB) syndrome or detrusor overactivity (DO)? 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