{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T11:45:30Z","timestamp":1778154330733,"version":"3.51.4"},"reference-count":20,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,2,10]],"date-time":"2017-02-10T00:00:00Z","timestamp":1486684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec><jats:title>AIMS<\/jats:title><jats:p>To compare efficacy of gabapentin and pregabalin in patients with urological chronic pelvic\u2010pain syndrome (UCPPS).<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Design\u2014retrospective, setting\u2014urology outpatient services of a secondary\u2010care private hospital, inclusion criteria\u2014men 18\u201050 years, presenting with pelvic pain (lower abdomen, groin, scrotum, perineum, low\u2010back, hip) with or without lower urinary tract symptoms for at least 3 months duration. Hospital database was searched using keywords for neuropathic pain (ICD9\u2014729.2, 719.45) and prostatitis (ICD9\u2014601.1, 601.9). Clinical data were retrieved from patient\u2010records, laboratory and radiology data, and analyzed using SPSS\u201019 statistical software.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Between Mar 2013 and Oct 2015, data of consecutive 119 patients fulfilling the above criteria was analyzed. Median age of patients was 35 years (IQR 29\u201043) and median duration of symptoms 12 months (IQR 6\u201024 months). Before treatment median VAS (0\u201010) pain score was 5 (IQR 4\u20106). Gabapentin was significantly more effective in controlling pain compared to pregabalin. Three fourth of patients on gabapentin alone (47\/62) reported at least 50% improvement in pain compared to only 40% on pregabalin alone (12\/30) (<jats:italic>P\u2009<\/jats:italic>=\u20090.0012; \u03c7<jats:sup>2<\/jats:sup>\u2009=\u20099.765. NNT 2.9, 95%CI 1.8\u20106.5). Twenty patients who were initially put on pregabalin had to switch to gabapentin for lack of efficacy. Forty four percent of patients on pregabalin required amitriptyline (24\/54) compared to only 13.6% of those on gabapentin (10\/72) required the same (<jats:italic>P<\/jats:italic> value of difference 0.0001; \u03c7<jats:sup>2<\/jats:sup>\u2009=\u200914.622. NNT 4, CI 95% 2.2\u20106.6).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Gabapentin may be more effective than pregabalin in UCPPS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.23225","type":"journal-article","created":{"date-parts":[[2017,2,10]],"date-time":"2017-02-10T06:02:45Z","timestamp":1486706565000},"page":"2028-2033","source":"Crossref","is-referenced-by-count":29,"title":["Gabapentenoids in pain management in urological chronic pelvic pain syndrome: Gabapentin or pregabalin?"],"prefix":"10.1002","volume":"36","author":[{"given":"Mayank Mohan","family":"Agarwal","sequence":"first","affiliation":[{"name":"Department of Urology NMC Specialty Hospital Abu Dhabi United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mudelin","family":"Elsi Sy","sequence":"additional","affiliation":[{"name":"Department of Urology NMC Specialty Hospital Abu Dhabi United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,2,10]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"952","volume-title":"Campbell\u2010Walsh Urology","author":"Nickel JC","year":"2015"},{"key":"e_1_2_6_3_1","article-title":"Guidelines on chronic pelvic pain","author":"Engeler D","year":"2014","journal-title":"Eur Assoc of Urol"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0140250"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2010.319"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0153037"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00508-005-0464-2"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.2190\/EXRP-J206-CBWT-UTFK"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2013.09.024"},{"key":"e_1_2_6_10_1","first-page":"CD007938","article-title":"Gabapentin for chronic neuropathic pain and fibromyalgia in adults","volume":"4","author":"Moore RA","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.22388"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2005.11.003"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.4103\/0253-7613.91867"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-015-2837-z"},{"key":"e_1_2_6_15_1","first-page":"CD007076","article-title":"Pregabalin for acute and chronic pain in adults","volume":"3","author":"Moore RA","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e318249d36e"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/aas.12766"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000001944"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000082710.47402.03"},{"key":"e_1_2_6_20_1","first-page":"47","article-title":"Oral gabapentin (Neurontin) treatment of refractory genitourinary tract pain","volume":"7","author":"Sasaki K","year":"2001","journal-title":"Tech Urol"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)68562-X"}],"container-title":["Neurourology and Urodynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fnau.23225","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.23225","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T02:56:32Z","timestamp":1696042592000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/nau.23225"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,10]]},"references-count":20,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1002\/nau.23225"],"URL":"https:\/\/doi.org\/10.1002\/nau.23225","archive":["Portico"],"relation":{},"ISSN":["0733-2467","1520-6777"],"issn-type":[{"value":"0733-2467","type":"print"},{"value":"1520-6777","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,10]]}}}