{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T10:55:06Z","timestamp":1784544906029,"version":"3.55.0"},"reference-count":16,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,2,14]],"date-time":"2017-02-14T00:00:00Z","timestamp":1487030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec><jats:title>AIMS<\/jats:title><jats:p>To evaluate the effectiveness and reliability of onabotulinum toxin A (onaBoNT\u2010A) injections in pediatric patients with non\u2010neurogenic detrusor overactivity (NNDO).<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Between January 2010 and February 2016, 39 patients underwent onaBoNT\u2010A injections for NNDO, and were evaluated retrospectively. Three\u2010day voiding diary was filled at baseline, and at the postoperative 9th month. The voiding frequency, incontinence episodes, and the cystometric capacity were noted. Vesicoureteral reflux (VUR) associated with NNDO, and presence of nocturia were recorded. Additional injection requirements were also stated.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>We reached the data of 33 patients on 9th month. The mean age was determined as 8.75\u2009\u00b1\u20093.01 (5\u201016) years. Initially, the mean bladder capacity was calculated as 114.66\u2009\u00b1\u200935.23\u2009mL on the voiding diary, and 153.15\u2009\u00b1\u200947.40\u2009mL on the baseline urodynamic study. After the procedures, the mean bladder capacity increased to 140.84\u2009\u00b1\u200945.61\u2009mL (<jats:italic>P<\/jats:italic>\u2009=\u20090.0011), the mean daily voiding frequency decreased from 10.36\u2009\u00b1\u20091.05 to 7.42\u2009\u00b1\u20090.83 (<jats:italic>P<\/jats:italic>\u2009=\u20090.01), and the mean incontinence episodes decreased from 2.72\u2009\u00b1\u20091.87 to 1.18\u2009\u00b1\u20091.13 (<jats:italic>P<\/jats:italic>\u2009=\u20090.001), on voiding diary. VUR associated with NNDO was determined in 10 (30.3%) patients. The degree of VUR decreased three in patients, and VUR disappeared in five patients following the injections (<jats:italic>P<\/jats:italic>\u2009=\u20090.011). Fourteen (42.4%) patients had nocturia, and after the injections, nocturia disappeared in five (15.15%) patients (<jats:italic>P<\/jats:italic>\u2009=\u20090.151). Additional injections were required in 10 (30.3%) patients at the 9th month.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>OnaBoNT\u2010A injections can be used in the pediatric patients with NNDO as an effective and reliable procedure by decreasing voiding frequency, incontinence episodes, and increasing bladder capacity, with negligible side effects and complications.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.23240","type":"journal-article","created":{"date-parts":[[2017,2,14]],"date-time":"2017-02-14T11:02:39Z","timestamp":1487070159000},"page":"2078-2082","source":"Crossref","is-referenced-by-count":12,"title":["Efficacy of onabotulinum toxin A injection in pediatric patients with non\u2010neurogenic detrusor overactivity"],"prefix":"10.1002","volume":"36","author":[{"given":"Omer","family":"Bayrak","sequence":"first","affiliation":[{"name":"Department of Urology University of Gaziantep Gaziantep Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erkan","family":"Sadioglu","sequence":"additional","affiliation":[{"name":"Department of Urology University of Gaziantep Gaziantep Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haluk","family":"Sen","sequence":"additional","affiliation":[{"name":"Department of Urology University of Gaziantep Gaziantep Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazim","family":"Dogan","sequence":"additional","affiliation":[{"name":"Department of Urology University of Gaziantep Gaziantep Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakip","family":"Erturhan","sequence":"additional","affiliation":[{"name":"Department of Urology University of Gaziantep Gaziantep Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilker","family":"Seckiner","sequence":"additional","affiliation":[{"name":"Department of Urology University of Gaziantep Gaziantep Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2007.05.014"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.purol.2009.02.001"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(01)01641-7"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2007.06575.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2009.01.005"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2007.08.052"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.2008.02016.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2006.07.022"},{"key":"e_1_2_6_10_1","first-page":"237","volume-title":"Uriner Inkontinans Tan\u0131 ve Tedavi","author":"Demirta\u015f A","year":"2015"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(06)00301-6"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1246193"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2014.04.004"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2012.08.011"},{"key":"e_1_2_6_15_1","first-page":"844","article-title":"Vesicoureteral reflux in overactive bladder: medical resolution through botulin toxin injection","volume":"65","author":"Arrabal\u2010Polo MA","year":"2012","journal-title":"Arch Esp Urol"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2016.03.146"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2016.04.046"}],"container-title":["Neurourology and Urodynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fnau.23240","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.23240","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T02:56:40Z","timestamp":1696042600000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/nau.23240"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,14]]},"references-count":16,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1002\/nau.23240"],"URL":"https:\/\/doi.org\/10.1002\/nau.23240","archive":["Portico"],"relation":{},"ISSN":["0733-2467","1520-6777"],"issn-type":[{"value":"0733-2467","type":"print"},{"value":"1520-6777","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,14]]}}}