{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T07:48:12Z","timestamp":1773215292142,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,3,3]],"date-time":"2017-03-03T00:00:00Z","timestamp":1488499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec><jats:title>AIMS<\/jats:title><jats:p>The ultrasound assessment of bladder wall thickness (BWT) and intravesical prostatic protrusion (IPP) have emerged as a non\u2010invasive, inexpensive, time\u2010saving alternatives to pressure\u2010flow studies to assess benign prostatic obstruction (BPO). Aim of our study was to evaluate the effect on detrusor mass of dutasteride add\u2010on therapy in men with lower urinary tract symptoms (LUTS) and benign prostatic enlargement (BPE).<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>A consecutive series of BPE patients with a prostate volume (PV) \u226530\u2009mL and an international prostate symptoms score (IPSS) \u22658 not satisfied with Tamsulosin monotherapy were enrolled. Free maximum flow (Qmax), PV, BWT, and IPP were recorded at baseline and at 24 weeks follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Overall, 27 men were enrolled. Dutasteride significantly improved LUTS (\u221246.7%; <jats:italic>P<\/jats:italic>\u2009=\u20090.001) and Qmax (+18.7%; <jats:italic>P<\/jats:italic>\u2009=\u20090.001) and reduced PV (\u221213%; <jats:italic>P<\/jats:italic>\u2009=\u20090.002), BWT (\u221240.3%; <jats:italic>P<\/jats:italic>\u2009=\u20090.001), and IPP (\u221214.9%; <jats:italic>P<\/jats:italic>\u2009=\u20090.015). At baseline, based on BWT \u22655\u2009mm and an IPP &gt;10\u2009mm, 13\/27 (48%) and 15\/27 (55%) patients were defined at risk for BPO, respectively; while after 24 weeks of treatment they were 3\/27 (11.1%) and 11\/27 (40%), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Dutasteride add\u2010on therapy significantly reduced IPP and detrusor mass and was effective in improving LUTS in patients with BPE not satisfied with \u03b1Bs monotherapy. The possible role of BWT and IPP as proxies of medical treatment outcomes should be confirmed by further studies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.23247","type":"journal-article","created":{"date-parts":[[2017,3,3]],"date-time":"2017-03-03T20:56:42Z","timestamp":1488574602000},"page":"2096-2100","source":"Crossref","is-referenced-by-count":6,"title":["Dutasteride add\u2010on therapy reduces detrusor mass in patients with benign prostatic enlargement not satisfied with alpha\u2010adrenergic antagonist monotherapy: A single center prospective study"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2190-512X","authenticated-orcid":false,"given":"Cosimo","family":"De Nunzio","sequence":"first","affiliation":[{"name":"Department of Urology, Ospedale Sant'Andrea \u201cLa Sapienza\u201d University Rome 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