{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T02:10:15Z","timestamp":1770516615579,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,4,18]],"date-time":"2017-04-18T00:00:00Z","timestamp":1492473600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006044","name":"Astellas Pharma Europe","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006044","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>To evaluate the effect on urethral pressure of reference drugs known to reduce stress urinary incontinence symptoms by different effect size and mechanisms of action on urethral musculature under four test conditions in healthy female subjects using urethral pressure reflectometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Healthy females aged 18\u201055 years were recruited by advertising for this phase 1, single site, placebo\u2010controlled, randomized, four\u2010period, crossover study. The interventions were single oral doses of 10\u2009mg Midodrine, 80\u2009mg Duloxetine, 12\u2009mg Reboxetine, and placebo. The endpoints were the opening urethral pressure measured in each period at four time points (predose and 2, 5.5, and 9\u2009h after dosing).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010nine females were enrolled; 25 randomized and 24 completed the study. The opening urethral pressure was higher in all measurements with filled bladder compared with empty bladder, and during squeezing compared to the resting condition. All three drugs increased the opening urethral pressure during all four conditions with a ranking of their effect on urethral pressure matching their reported clinical effect (difference vs. placebo at their reported time of peak plasma concentrations [T<jats:sub>max<\/jats:sub>] during resting with filled bladder: Midodrine 9.3\u2009cmH<jats:sub>2<\/jats:sub>O [95%CI 3.0, 15.5], Duloxetine 24.2\u2009cmH<jats:sub>2<\/jats:sub>O [95%CI 17.9, 30.5], and Reboxetine 44.9\u2009cmH<jats:sub>2<\/jats:sub>O [95% CI 40.2, 52.8] cmH<jats:sub>2<\/jats:sub>O).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Urethral pressure reflectometry is capable of detecting drug\u2010induced changes in urethral tone in various conditions. The magnitude of drug\u2010induced changes by the test drugs seems to match their clinical profile and differences in mode of action.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.23282","type":"journal-article","created":{"date-parts":[[2017,4,18]],"date-time":"2017-04-18T16:45:15Z","timestamp":1492533915000},"page":"244-249","source":"Crossref","is-referenced-by-count":16,"title":["The effect of single oral doses of duloxetine, reboxetine, and midodrine on the urethral pressure in healthy female subjects, using urethral pressure reflectometry"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1906-3135","authenticated-orcid":false,"given":"Niels","family":"Klarskov","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Herlev Hospital University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk","family":"Cerneus","sequence":"additional","affiliation":[{"name":"Astellas Pharma Europe BV Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Sawyer","sequence":"additional","affiliation":[{"name":"Astellas Pharma Europe BV Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald","family":"Newgreen","sequence":"additional","affiliation":[{"name":"Astellas Pharma Europe BV Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"van Till","sequence":"additional","affiliation":[{"name":"Astellas Pharma Europe BV Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunnar","family":"Lose","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Herlev Hospital University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,4,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2006.09.019"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-014-2512-9"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006254-200111000-00024"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20283"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2007.06922.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.01.114"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(08)61675-4"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02001083"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-013-2269-6"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365598309182128"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.2165\/11539240-000000000-00000"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200039060-00003"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(08)61536-0"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-016-2964-1"},{"key":"e_1_2_8_16_1","first-page":"B4412","article-title":"Urethral pressure reflectometry. A method for simultaneous measurements of pressure and cross\u2010sectional area in the female urethra","volume":"59","author":"Klarskov N","year":"2012","journal-title":"Dan Med J"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007990903438295"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-4295(87)90314-1"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-4295(88)90400-1"},{"key":"e_1_2_8_20_1","first-page":"119","article-title":"Pharmacokinetic parameters and haemodynamic actions of midodrine in young volunteers","volume":"12","author":"Grobecker HF","year":"1993","journal-title":"Int Angiol"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-006-0230-7"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/luts.12057"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2006.00877.x"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00297.2009"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2006.08.041"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.07.016"}],"container-title":["Neurourology and Urodynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fnau.23282","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.23282","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/nau.23282","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.23282","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T07:17:07Z","timestamp":1694243827000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/nau.23282"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,18]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1002\/nau.23282"],"URL":"https:\/\/doi.org\/10.1002\/nau.23282","archive":["Portico"],"relation":{},"ISSN":["0733-2467","1520-6777"],"issn-type":[{"value":"0733-2467","type":"print"},{"value":"1520-6777","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,18]]}}}