{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:40:04Z","timestamp":1792176004513,"version":"4.4.0"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,6,15]],"date-time":"2017-06-15T00:00:00Z","timestamp":1497484800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008492","name":"Swiss Continence Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008485","name":"Schweizerische Akademie der Medizinischen Wissenschaften","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008485","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>To systematically assess all available evidence on efficacy and safety of vanilloids for treating neurogenic lower urinary tract dysfunction (NLUTD) in patients with multiple sclerosis (MS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This systematic review and meta\u2010analysis was performed according to the Preferred Reporting Items for Systematic Reviews and Meta\u2010Analyses (PRISMA) statement. Studies were identified by electronic search of Cochrane register, Embase, Medline, Scopus, (last search January 8, 2016).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After screening of 7848 abstracts, 4 randomized controlled trials (RCTs) and 3 prospective cohort studies were included. Pooled data from three RCTs evaluating intravesical capsaicin showed the standardized mean difference to be \u22122.16 (95% confidence interval [CI] \u22122.87 to \u22121.45) in incontinence episodes per 24\u2009h and \u22120.54 (95%CI \u22121.03 to \u22120.05) in voids per 24\u2009h. There was no statistically significant effect on maximum cystometric capacity and maximum storage detrusor pressure. Overall, adverse events were reported by &gt;50% of the patients, most commonly were pelvic pain, facial flush, worsening of incontinence, autonomic dysreflexia, urinary tract infection and haematuria. Risk of bias and confounding was relevant in both RCTs and non\u2010RCTs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Preliminary data suggest that intravesical vanilloids might be effective for treating NLUTD in patients with MS. However, the safety profile seems unfavorable, the overall quality of evidence is low and no licensed substance is currently available warranting well\u2010designed, adequately sampled and properly powered RCTs.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.23314","type":"journal-article","created":{"date-parts":[[2017,6,15]],"date-time":"2017-06-15T21:41:06Z","timestamp":1497562866000},"page":"67-82","source":"Crossref","is-referenced-by-count":19,"title":["Intravesical vanilloids for treating neurogenic lower urinary tract dysfunction in patients with multiple sclerosis: A systematic review and meta\u2010analysis. A report from the Neuro\u2010Urology Promotion Committee of the International Continence Society (ICS)"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4997-6763","authenticated-orcid":false,"given":"V\u00e9ronique","family":"Ph\u00e9","sequence":"first","affiliation":[{"name":"Department of Urology, Piti\u00e9\u2010Salp\u00eatri\u00e8re Academic Hospital Assistance Publique\u2010H\u00f4pitaux de Paris, Pierre et Marie Curie Medical School, Sorbonne Universit\u00e9s, Paris 6 University Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc P.","family":"Schneider","sequence":"additional","affiliation":[{"name":"Neuro\u2010Urology, Spinal Cord Injury Center &amp; Research University of Z\u00fcrich, Balgrist University Hospital Z\u00fcrich Switzerland"},{"name":"Brain Research Institute, University of Z\u00fcrich, and Department of Health Sciences and Technology Swiss Federal Institute of Technology Z\u00fcrich Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit","family":"Peyronnet","sequence":"additional","affiliation":[{"name":"Department of Urology Pontchaillou Hospital Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadim","family":"Abo Youssef","sequence":"additional","affiliation":[{"name":"Neuro\u2010Urology, Spinal Cord Injury Center &amp; Research University of Z\u00fcrich, Balgrist University Hospital Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livio","family":"Mordasini","sequence":"additional","affiliation":[{"name":"Department of Urology Cantonal Hospital Lucerne Lucerne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Chartier\u2010Kastler","sequence":"additional","affiliation":[{"name":"Department of Urology, Piti\u00e9\u2010Salp\u00eatri\u00e8re Academic Hospital Assistance Publique\u2010H\u00f4pitaux de Paris, Pierre et Marie Curie Medical School, Sorbonne Universit\u00e9s, Paris 6 University Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas M.","family":"Bachmann","sequence":"additional","affiliation":[{"name":"Medignition Inc. 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