{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:36:05Z","timestamp":1790516165222,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,6,13]],"date-time":"2017-06-13T00:00:00Z","timestamp":1497312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We examined the effect of an E\u2010series prostaglandin 1 (EP1) receptor antagonist on bladder activity using a rat model of spinal cord injury (SCI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Female Sprague\u2010Dawley rats were used. Six weeks after spinal cord transection, conscious\u2010filling cystometry was performed. We evaluated the urodynamic parameters before and after intravenous (0.1 and 1.0\u2009mg\/kg) or intrathecal (0.1 and 1.0\u2009\u00b5g) administration of SC51089, an EP1 antagonist. Spinal prostaglandin E2 (PGE2) concentration and EP1 receptor transcripts in the spinal cord and dorsal root ganglia (DRG) were measured by enzyme\u2010linked immunosorbent assay and RT\u2010PCR, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The time to the first non\u2010voiding contraction (NVC) was significantly prolonged after both 0.1 and 1.0\u2009mg\/kg of intravenous administration of SC51089 (75% prolongation at 1.0\u2009mg\/kg) whereas other parameters were not significantly changed compared to vehicle treatment. In addition, the time to the first NVC was also significantly prolonged after 1.0\u2009\u00b5g of intrathecal administration of SC51089 (18% prolongation at 1.0\u2009\u00b5g) whereas other parameters were not significantly changed. The spinal PGE2 concentration in SCI rats was significantly higher than that in spinal intact rats. The mRNA expressions of EP1 receptors in the both spinal cord and DRG from SCI rats were significantly higher than those from spinal intact rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The PGE2\u2010induced activation of EP1 receptors in the spinal cord contributes to the initiation of detrusor overactivity in SCI. Thus, the EP1 receptor could be a therapeutic target for the treatment of neurogenic detrusor overactivity due to SCI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/nau.23319","type":"journal-article","created":{"date-parts":[[2017,6,13]],"date-time":"2017-06-13T09:07:09Z","timestamp":1497344829000},"page":"132-137","source":"Crossref","is-referenced-by-count":6,"title":["Urodynamic effects of intravenous and intrathecal administration of E\u2010series prostaglandin 1 receptor antagonist on detrusor overactivity in rats with spinal cord injury"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9587-6798","authenticated-orcid":false,"given":"Naoki","family":"Wada","sequence":"first","affiliation":[{"name":"Department of Urology University of Pittsburgh School of Medicine Pittsburgh Pennsylvania"},{"name":"Department of Renal and Urologic Surgery Asahikawa Medical University Asahikawa 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