{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:21:23Z","timestamp":1790014883984,"version":"4.0.1"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,7,26]],"date-time":"2017-07-26T00:00:00Z","timestamp":1501027200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Aims of this study were to assess the long\u2010term outcomes of Intradetrusor injection of OnabotulinumtoxinA (Botox\u00ae injection) associated with clean intermittent\u2010catheterization (CIC) for the treatment of neurogenic detrusor overactivity (NDO) and to identify risk factors for failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Neurological patients with NDO using CIC who had received Botox\u00ae injections between January 2001 and September 2013 were included. Clinical, urodynamic and radiological data were recorded. Primary endpoint was failure and withdrawal rates after 3, 5, and 7 years of management. Survival curves of withdrawals and failures of treatment were calculated with a 95\u2010confidence interval using the Kaplan\u2010Meier method. Risk factors for failure were determined with univariate analysis and multivariate analysis using Cox model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 292 patients, mean age of 40\u2009\u00b1\u200913, 6 years, were included. Overall, 219 patients (80.6%; IC95% [76.3\u201085.4%]) were still treated with Botox\u00ae injections after 3 years, 128 (71.1%; IC95% [65.7%, 76.9%]) after 5 years, and 58 (60.8%, IC95% [54.0%, 68.4%]) after 7 years. Failure rate was 12.6% (IC95% [8.6\u201016.5%]) after 3 years, 22.2% (IC95% [16.6\u201027.3%]) after 5 years, and 28.9% (IC95% [21.9%; 35.3%]) after 7 years of follow\u2010up. Withdrawal rate after 7 years of follow\u2010up was 11.3% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200933\/292). Severe NDO at baseline appears to be a significant risk factor for failure.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study confirms long\u2010term efficacy and tolerance of Botox\u00ae injection in patients with NDO using CIC. Long\u2010term failure and withdrawal rates remain low but significant, and need to be managed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/nau.23352","type":"journal-article","created":{"date-parts":[[2017,7,26]],"date-time":"2017-07-26T12:12:56Z","timestamp":1501071176000},"page":"799-806","source":"Crossref","is-referenced-by-count":35,"title":["Long\u2010term outcomes and risks factors for failure of intradetrusor onabotulinumtoxin A injections for the treatment of refractory neurogenic detrusor overactivity"],"prefix":"10.1002","volume":"37","author":[{"given":"Charles","family":"Joussain","sequence":"first","affiliation":[{"name":"Medical School Paris \u00cele\u2010de\u2010France Ouest, Inserm U1179 Versailles Saint\u2010Quentin University Versailles France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9lanie","family":"Popoff","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation H\u00f4pital 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