{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:41:01Z","timestamp":1792176061306,"version":"4.4.0"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,7,26]],"date-time":"2017-07-26T00:00:00Z","timestamp":1501027200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81370862"],"award-info":[{"award-number":["81370862"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the value of repeat botulinum toxin A (BTX\u2010A) injections in patients with neurogenic detrusor overactivity (NDO).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched the PubMed, EMBASE, and EBSCO databases for articles published until June 2016. Studies that reported the efficacy and safety of repeat BTX\u2010A injections for adult patients with NDO were eligible. The effect size for each outcome was calculated as the standardized mean difference\u2009\u00b1\u2009standard error and 95% confidence interval, and was graded as small, &gt;0.2; moderate, &gt;0.5; or large, &gt;0.8. The outcomes included maximum cystometric capacity (MCC), maximum detrusor pressure (MDP), reflex volume (RV), bladder compliance (BC), quality of life (QOL), and injection interval. Descriptive reviews were performed for urinary incontinence (UI) and adverse events (AEs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighteen studies involving 1533 patients whose level of evidence ranged from 3 to 4 were included in this study. We noted non\u2010significant changes in MCC, MDP, RV, and BC between the first and last injections. Patients who had received \u22644 injections were found to have stable QOL improvements after the first and last injections, whereas patients who had received \u22655 injections were found to have a significant decrease in QOL after the last injection. No significant differences in injection intervals were noted after repeat BTX\u2010A injections, and the repeat injection failure rate was low.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study demonstrated that repeat BTX\u2010A injections allow sustained improvements in patients with NDO. The rate of AEs was stable and low. However, additional high\u2010quality, large\u2010scale, and long\u2010term trials are necessary to establish the efficacy and safety of \u22655 repeat BTX\u2010A injections.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.23354","type":"journal-article","created":{"date-parts":[[2017,7,26]],"date-time":"2017-07-26T16:11:11Z","timestamp":1501085471000},"page":"542-553","source":"Crossref","is-referenced-by-count":31,"title":["Is repeat Botulinum Toxin A injection valuable for neurogenic detrusor overactivity\u2014A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"37","author":[{"given":"Jianshu","family":"Ni","sequence":"first","affiliation":[{"name":"Department of Urology Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Urology Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9328-6543","authenticated-orcid":false,"given":"Nailong","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Urology Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiemin","family":"Si","sequence":"additional","affiliation":[{"name":"Department of Urology Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5090-3767","authenticated-orcid":false,"given":"Baojun","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Urology Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410X.1997.00191.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002060-200112000-00008"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458506075651"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0016718"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2010.187"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200003023420918"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2007.10.013"},{"key":"e_1_2_6_9_1","unstructured":"HowickJ ChalmersI GlasziouP et al. 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