{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T12:09:35Z","timestamp":1778933375711,"version":"3.51.4"},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Philanthropy-Ministrelli Program for Urology Research and Education"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>To examine the relationship between coexisting depressive symptoms and outcomes after staged neuromodulation procedures for refractory urological symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Adults who enrolled in a prospective database and completed a Personal Health Questionnaire Depression Scale (PHQ\u20108) at baseline were reviewed. The PHQ\u20108 and Generalized Anxiety Disorder (GAD\u20107) assessed depressive\/anxiety symptoms pre and 6 months post device implant. Urological symptoms were assessed with The Interstitial Cystitis Symptom Index\/Problem Index (ICSI\u2010PI) and Overactive Bladder Questionnaire (OAB\u2010q) at baseline, 3 and 6 months, and Global Response Assessments (GRA) post implant. Subjects, grouped by PHQ\u2009&lt;10 and PHQ \u226510, were compared with Pearson's Chi\u2010square, Fisher's Exact or Wilcoxon rank test, and Spearman's correlations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 117 PHQ &lt;10 and 84 PHQ \u226510 patients, age differed (mean 59 vs 52 years; <jats:italic>P<\/jats:italic>\u2009=\u20090.001), and PHQ &lt;10 had lower GAD\u20107, ICSI\u2010PI, and OAB\u2010q scores at baseline (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001, <jats:italic>P<\/jats:italic>\u2009=\u20090.0003, and <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0008, respectively). Implantation rates were similar between groups. Reoperation and complication rates within the first 6 months did not differ, similar proportions (majority) were improved on the GRA at each time point, and ICSI\u2010PI and OAB\u2010q scores improved significantly. PHQ scores only improved significantly for those with baseline PHQ \u226510. Baseline PHQ strongly correlated with GAD\u20107 at baseline and 6 months, and baseline ICSI\u2010PI. Change in PHQ positively correlated with the change in GAD\u20107, 6 month ICSI\u2010PI, and change in ICSI\u2010PI from baseline to 6 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Coexisting depressive symptoms do not limit the efficacy of neuromodulation and PHQ improvements correlate with improved anxiety and bladder symptoms.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.23356","type":"journal-article","created":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T11:16:57Z","timestamp":1501586217000},"page":"815-822","source":"Crossref","is-referenced-by-count":4,"title":["Coexisting depressive symptoms do not limit the benefits of chronic neuromodulation: A study of over 200 patients"],"prefix":"10.1002","volume":"37","author":[{"given":"Kim A.","family":"Killinger","sequence":"first","affiliation":[{"name":"Beaumont Health Royal Oak Michigan"},{"name":"Oakland University William Beaumont School of Medicine Rochester Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Fergus","sequence":"additional","affiliation":[{"name":"Oakland University William Beaumont School of Medicine Rochester Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luke","family":"Edwards","sequence":"additional","affiliation":[{"name":"Beaumont Health Royal Oak Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith A.","family":"Boura","sequence":"additional","affiliation":[{"name":"Beaumont Health Royal Oak Michigan"},{"name":"Oakland University William Beaumont School of Medicine Rochester Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamie","family":"Bartley","sequence":"additional","affiliation":[{"name":"Beaumont Health Royal Oak Michigan"},{"name":"Oakland University William Beaumont School of Medicine Rochester Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priyanka","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Urology University of Michigan Ann Arbor Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janice","family":"Tomakowsky","sequence":"additional","affiliation":[{"name":"Beaumont Health Royal Oak Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Gilleran","sequence":"additional","affiliation":[{"name":"Beaumont Health Royal Oak Michigan"},{"name":"Oakland University William Beaumont School of Medicine Rochester Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth M.","family":"Peters","sequence":"additional","affiliation":[{"name":"Beaumont Health Royal Oak Michigan"},{"name":"Oakland University William Beaumont School of Medicine Rochester Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11934-011-0204-2"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20823"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20786"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2016.04.024"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2005.10.019"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.5435\/00124635-200607000-00002"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2008.06.026"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.10.1092"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2007.09.007"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.PSY.0000038940.33335.09"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2014.11.019"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/SPV.0000000000000062"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.22871"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12894-016-0179-x"}],"container-title":["Neurourology 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