{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:50:41Z","timestamp":1786978241007,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,7,26]],"date-time":"2017-07-26T00:00:00Z","timestamp":1501027200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To evaluate the ability of TAC\u2010302, a cyclohexenoic fatty alcohol derivative, to enhance neurite outgrowth in cultured rat dorsal root ganglion (DRG) neurons, and the preventive effects of TAC\u2010302 on bladder denervation\u2010related storage and voiding dysfunctions in rats with bladder outlet obstruction (BOO).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Rat DRG neurons were cultured in the presence of TAC\u2010302. Cell numbers and neurite lengths were quantified after a 24\u2009h culture. BOO was achieved by partial ligature of the proximal urethra in female rats. BOO rats were divided into three groups and orally treated with vehicle of 3 or 30\u2009mg\/kg TAC\u2010302 twice a day for 4 weeks. Cystometry was performed under conscious conditions. Immunohistochemical staining using anti\u2010PGP9.5 of the bladder muscle layer was performed, and the innervation area was scored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      TAC\u2010302 significantly and dose\u2010dependently increased neurite outgrowth in cultured DRG neurons. BOO rats showed a decreased innervation area in the urinary bladder compared to sham\u2010operated rats. BOO\u2010induced denervation of the urinary bladder was partially prevented by oral treatment with TAC\u2010302. TAC\u2010302 significantly reduced the frequency of non\u2010voiding contraction (NVC) and residual urine volume (RUV) compared with the BOO vehicle group (\n                      <jats:italic>P\u2009<\/jats:italic>\n                      &lt;\u20090.05). The innervation area score exhibited significant negative correlations with NVC and RUV, indicating that they increased according to the progression of denervation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our data indicate that TAC\u2010302 promotes neurite outgrowth in vitro. In addition, TAC\u2010302 prevents BOO\u2010induced bladder dysfunction in rats, and has a protective effect on bladder denervation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/nau.23375","type":"journal-article","created":{"date-parts":[[2017,7,26]],"date-time":"2017-07-26T12:14:38Z","timestamp":1501071278000},"page":"681-689","source":"Crossref","is-referenced-by-count":11,"title":["TAC\u2010302 promotes neurite outgrowth of isolated peripheral neurons and prevents bladder denervation related bladder dysfunctions following bladder outlet obstruction in rats"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2294-2387","authenticated-orcid":false,"given":"Shohei","family":"Yoshida","sequence":"first","affiliation":[{"name":"Taiho Pharmaceutical Co. Ltd. Tsukuba Research Center Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Orimoto","sequence":"additional","affiliation":[{"name":"Taiho Pharmaceutical Co. Ltd. Tsukuba Research Center Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Tsukihara","sequence":"additional","affiliation":[{"name":"Taiho Pharmaceutical Co. Ltd. Tsukuba Research Center Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahisa","family":"Noma","sequence":"additional","affiliation":[{"name":"Taiho Pharmaceutical Co. Ltd. Tsukuba Research Center Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Hakozaki","sequence":"additional","affiliation":[{"name":"Taiho Pharmaceutical Co. Ltd. Tsukuba Research Center Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiji","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Taiho Pharmaceutical Co. Ltd. Tsukuba Research Center Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.10052"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2006.09.019"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2006.04.018"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.12652"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.1987.tb05033.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)44930-5"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2008.10.032"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(01)03007-4"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(90)90985-K"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/51201439"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-008-0484-x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2007.07307.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)64573-7"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2006.06.054"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)67951-7"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)43675-5"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)67204-7"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.1987.tb04979.x"},{"key":"e_1_2_8_20_1","unstructured":"KokubunS ShishidoK TakahashiN et al. Neuron protection agent TAC\u2010302 prevents bladder denervation and dysfunction following partial bladder obstruction in rats. Poster presented at ICS\u2010IUGA annual meeting; August 23\u201027 2010; Toronto Canada."},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00009.2003"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2010.11.040"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)56918-9"},{"key":"e_1_2_8_24_1","first-page":"1508","article-title":"Influence of bladder outlet obstruction and detrusor contractility on residual urine in patients with benign prostatic hyperplasia","volume":"116","author":"Zhang P","year":"2003","journal-title":"Chin Med J (Engl)"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)35867-6"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)41520-5"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.1992.tb15791.x"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.04.101"}],"container-title":["Neurourology and Urodynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fnau.23375","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.23375","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T01:19:48Z","timestamp":1694654388000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/nau.23375"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,26]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1002\/nau.23375"],"URL":"https:\/\/doi.org\/10.1002\/nau.23375","archive":["Portico"],"relation":{},"ISSN":["0733-2467","1520-6777"],"issn-type":[{"value":"0733-2467","type":"print"},{"value":"1520-6777","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,26]]}}}